Providing Quality 3D Cell Culture Systems for
Tissue Engineering and Stem Cell Culture Applications

Tissue Engineering

NASA-Approved Rotary Bioreactor Enhances Proliferation of Human Epidermal Stem Cells and Supports Formation of 3D Epidermis-Like Structure.

Lei XH, Ning LN, Cao YJ, Liu S, Zhang SB, Qiu ZF, Hu HM, Zhang HS, Liu S, Duan EK.PLoS One. 6(11):e26603; Nov 2011 [abstract] [full text] [full text pdf]

Development of a novel three-dimensional, automatable and integrated bioprocess for the differentiation of embryonic stem cells into pulmonary alveolar cells in a rotating vessel bioreactor system. 

Ismail S, Samadikuchaksaraei A, Bishop A, Polak JM, Mantalaris A.Tissue Eng Part C Methods. Epub Nov 2011 [abstract]

The simulated microgravity enhances the differentiation of mesenchymal stem cells into neurons.

Chen J, Liu R, Yang Y, Li J, Zhang X, Li J, Wang Z, Ma J. Neurosci Lett.;505(2):171-5. Nov 2011 [abstract]

3D sample preparation for orthopaedic tissue engineering bioreactors. 

Cartmell SH, Rathbone S, Jones G, Hidalgo-Bastida LA. (Textbook chapter in 3D Cell Culture: Methods and Protocols, ISBN 978-1-60761-983-3) [abstract]

An epidermal stem cells niche microenvironment created by engineered human amniotic membrane.

Ji SZ, Xiao SC, Luo PF, Huang GF, Wang GY, Zhu SH, Wu MJ, Xia ZF Biomaterials.;32(31):7801-11, Nov 2011 [Abstract]

Enhanced cardiac differentiation of mouse embryonic stem cells by use of the slow-turning, lateral vessel (STLV) bioreactor.

Rungarunlert S, Klincumhom N, Bock I, Nemes C, Techakumphu M, Pirity MK, Dinnyes A. Biotechnol Lett. 2011 Aug;33(8):1565-73, 2011 [Abstract]

Bioreactor systems for bone tissue engineering.

Rauh J, Milan F, Günther KP, Stiehler M. Tissue Eng Part B Rev. 2011 Aug;17(4):263-80. [Abstract]

RCCS enhances EOE cell proliferation and their differentiation into ameloblasts.

Li P, Zhang Y, Wang YM, Duan CM, Hao T, Wu BL, Wang CY. . Mol Biol Rep. Epub June 2011 [Abstract]

Reconstitution of hepatic tissue architectures from fetal liver cells obtained from a three-dimensional culture with a rotating wall vessel bioreactor.

Ishikawa M, Sekine K, Okamura A, Zheng YW, Ueno Y, Koike N, Tanaka J, Taniguchi H. J Biosci Bioeng. 111(6):711-8. June 2011 [Abstract]

Enhancement of matrix production and cell proliferation in human annulus cells under bioreactor culture.

Yang X, Wang D, Hao J, Gong M, Arlet V, Balian G, Shen FH, Li XJ. Tissue Eng Part A.; 17(11-12):1595-603, June 2011 [Abstract]

Computational modeling for the optimization of a cardiogenic 3D bioprocess of encapsulated embryonic stem cells.

Consolo F, Bariani C, Mantalaris A, Montevecchi F, Redaelli A, Morbiducci U. Biomech Model Mechanobiol., Apr 2011 [abstract]

Labeling of primary human hepatocytes with micron-sized iron oxide particles in suspension culture suitable for large-scale preparation.

Kammer NN, Billecke N, Morgul MH, Adonopoulou MK, Mogl M, Huang MD, Florek S, Schmitt KR, Raschzok N, Sauer IM. Artif Organs. 35(4):E91-100. doi: 10.1111/j.1525-1594.2010.01177.x., 2011 [abstract]

Bone tissue engineering bioreactors: dynamic culture and the influence of shear stress.

Yeatts AB, Fisher JP. Bone; 48(2):171-81. 2011 [abstract]

Impact of Scaffold Micro and Macro Architecture on Schwann Cell Proliferation under Dynamic Conditions in a Rotating Wall Vessel Bioreactor.

Valmikinathan CM, Hoffman J, Yu X. Mater Sci Eng C Mater Biol Appl. 2011 Jan 1;31(1):22-29.[abstract]

Chondrocytes and bone marrow-derived mesenchymal stem cells undergoing chondrogenesis in agarose hydrogels of solid and channelled architectures respond differentially to dynamic culture conditions.

Sheehy EJ, Buckley CT, Kelly DJ., J Tissue Eng Regen Med. Epub Jan 2011 [abstract]

The effect of simulated microgravity on human mesenchymal stem cells cultured in an osteogenic differentiation system: a bioinformatics study.

Sheyn D, Pelled G, Netanely D, Domany E, Gazit D. Tissue Eng Part A. 16(11):3403-12, 2010 [abstract]

The generation of 3-D tissue models based on hyaluronan hydrogel-coated microcarriers within a rotating wall vessel bioreactor.

Skardal A, Sarker SF, Crabbé A, Nickerson CA, Prestwich GD., Biomaterials. 31(32):8426-35, 2010 [abstract]

Computational fluid dynamics modeling of momentum transport in rotating wall perfused bioreactor for cartilage tissue engineering.

Cinbiz MN, Tığli RS, Beşkardeş IG, Gümüşderelioğlu M, Colak U. J Biotechnol; 150(3):389-95; 2010[abstract]

Enhanced cell ingrowth and proliferation through three dimensional nano composite scaffolds with controlled pore structures.

Lee KW, Wang S, Dadsetan M, Yaszemski MJ, Lu L.  Biomacromolecules. 11:682-9, 2010. [abstract] [full text] [full text pdf]

Influence of acellular natural lung matrix on murine embryonic stem cell differentiation and tissue formation.

Cortiella J, Niles J, Cantu A, Brettler A, Pham A, Vargas G, Winston S, Wang J, Walls S, Nichols JE.  Tissue Eng Part A. 16(8):2565-80, 2010 [Abstract]

A validated model of GAG deposition, cell distribution and growth of tissue engineered cartilage cultured in a rotating bioreactor.

Nikolaev NI, Obradovic B, Versteeg HK, Lemon G, Williams DJ. Biotechnol Bioeng 105:842-853, 2010 [abstract]

NASA approved rotary bioreactor enhances proliferation and osteogenesis of human periodontal ligament stem cells.

Li S, Ma Z, Niu Z, Qian H, Xuan D, Hou R, Ni L.  Stem Cells Dev. 18:1273-82, 2009 [Abstract]

The use of murine embryonic stem cells, alginate encapsulation, and rotary microgravity bioreactor in bone tissue engineering.

Hwang YS, Cho J, Tay F, Heng JY, Ho R, Kazarian SG, Williams DR, Boccaccini AR, Polak JM, Mantalaris A. Biomaterials 30: 499-507, 2008 [Abstract]

Reconstruction of Functional Cortical-Like Tissues from Neural Stem and Progenitor Cells.

Ma W, Tavakoli T, Chen S, Maric D, Liu JL, O'Shaughnessy TJ.  Tissue Eng Part A 14: 1687-1697, 2008 [Abstract]

Cell-Nanofiber-Based Cartilage tissue Engineering Using Improved Cell Seeding, Growth Factor, and Bioreactor Technologies.

Li WJ, Jiang YJ, Tuan RS.  Tissue Eng Part A 14:639-648, 2008 [Abstract]

In-vitro reconstitution of hepatic tissue architecture with neonatal mouse liver cells using three –dimensional culture.

Okamura A, Zheng YW, Hirochika R, Tanaka J, Taniguchi H.  J Nanosci Nanotechnol 7: 721- 725, 2007 [Abstract]

Three-dimensional adipose tissue model using low shear bioreactors.

Fry CA, Patrick CW.  In Vitro Cell Dev Biol Anim. 42:109-114, 2006 [Abstract]

Tissue growth in a rotating bioreactor. Part I: mechanical stability.

Waters SL, Cummins LJ, Shakesheff KM, Rose FR. Math. Med. Biol. 23: 311-337, 2006 [Abstract]

Enhanced neurotrophin synthesis and molecular differentiation in non-transformed human retinal progenitor cells cultured in a rotating bioreactor.

Kumar R, Dutt K:  Tissue Eng. 12: 141-158, 2006. [Abstract]

A New Method for Constructing Large Tissue in Rotary Culture Vessels.

Su GN, Hidaka M, Kimura Y, Yamamoto G: In Situ Collagen Gelation:  In Vitro Cell Dev Biol Animl 39: 368-374, 2003. [Abstract]

Three-Dimensional Model of Angiogenesis: Coculture of Human Retinal Cells with Bovine Aortic Endothelial Cells in the NASA Bioreactor.

Dutt K, Sanford G, Harris-Hooker S, Brako L, Kumar R, Sroufe A, Melhado S:  Tissue Eng 9: 893-907 2003. [Abstract]

Generation of 3-D Retina-Like Structures From a Human Retinal Cell Line in a NASA Bioreactor.

Dutt K, Harris-HookerS, Ellerson D, Layne D, Kumar R, Hunt R:Cell Trans 12: 717-731, 2003 [Abstract]

Cytoskeletal and Functional Changes in Bioreactor Assembled Thyroid Tissue Organoids Exposed to Gamma Radiation.

Green LM, Patel Z, Murray DK, Rightnar S, Burell CG, Gridley DS, Nelson GA:  J Radiat. Res. 43: S213-S218, 2002. [Abstract] [Full Text] [Full Text pdf]

Three-dimensional Growth of Endothelial Cells in the Microgravity-Based Rotating Wall Vessel Bioreactor:

Sanford GL, Ellerson D, Melhado-Gardner C, Sroufe AE, Harris-Hooker S: In Vitro Cell Dev Biol Anim., 38: 493-504, 2002. [Abstract]

Spaceflight Bioreactor Studies of Cells and Tissues.

Freed LE, Vunjak-Novakovic G:  Adv Space Biol Med 8:177-195, 2002. [Abstract]

Formation of three-dimensional cell/polymer constructs for bone tissue engineering in a spinner flask and a rotating wall vessel bioreactor.

Sikavitsas VI, Bancroft GN, Mikos AG:  J Biomed Mater Res 62: 136-148, 2002. [Abstract]

Development of a Three-Dimensional Transmigration Assay for Testing Cell-Polymer Interactions for Tissue Engineering Applications.

Gosiewska A, Rezania A, Dhanaraj S, Vyakarnam M, Zhou J, Brown L, Kong W, Zimmerman M and Geesin JC:  Tissue Eng 7: 267-77, 2001. [Abstract]

Thyroid Organoid Formation in Simulated Microgravity: Influence of Keratinocyte Growth Factor.

Martin A, Zhou A, Gordon RE, Henderson SC, Schwartz AE, Friedman EW and Davies TF:  Thyroid 10: 481-487, 2000. [Abstract]

 Tissue Engineering Bioreactors.

Freed LE and Vunjak-Novakovic G: Principles of Tissue Engineering, 2nd Edition, Chapter 13, pp. 143-156, 2000. (Textbook)

Tissue Engineering: The Challenges Ahead.

Langer RS and Vacanti JP: Scientific American. 280: 86-89, 1999. 

Culture of Organized Cell Communities.

Freed LE and Vunjak-Novakovic G:  Adv Drug Delivery Reviews 33: 15-30, 1998. [Abstract]

The Use of Rotating Wall Bioreactors for the Assembly of Differentiated Tissue-Like Organoids.

Unsworth BR, Lelkes PI:  Advances in Tissue Engineering: New developments in cartilage, skin and bone engineering, Chap 2.3, pp. 113-32, 1998. (Textbook)

Microgravity Tissue Engineering.

Freed LE and Vunjak-Novakovic G:  In Vitro Cell Dev Biol Anim 33: 381-385, 1997. [Abstract]

A Novel Culture Morphology Resulting From Applied Mechanical Strain.

Grymes RA, Sawyer C:  In Vitro Cell Dev Biol Anim 33: 392-397, 1997. [Abstract]

Rotating-Wall Vessel Co-culture Of Small Intestine As A Prelude To Tissue Modeling.

Goodwin TJ, Schroeder WF, Wolf DA and Moyer MP:  Aspects of Simulated Microgravity. Proc Soc Exp Biol Med 202: 181-192, 1993. [Abstract]

Reduced Shear Stress: A Major Component in the Ability of Mammalian Tissues to Form Three Dimensional Assemblies in Simulated Microgravity.

Goodwin TJ, Prewett TL, Wolf DA and Spaulding GF: J Cell Biochem 51: 301-311, 1993. [Abstract]

GTSF-2: A New, Versatile Cell Culture Medium for Diverse Normal and Transformed Mammalian Cells.
Lelkes PI, Ramos E, Nikolaychik VV, Wankowski D, Unsworth B, Goodwin TJ:  In Vitro Cell Dev Biol Anim 33: 344-351, 1997. [Abstract]

 

Scroll To Top