Providing Quality 3D Cell Culture Systems for
Tissue Engineering and Stem Cell Culture Applications

Stem Cells

Freeze-dried human serum albumin improves the adherence and proliferation of mesenchymal stem cells on mineralized human bone allografts.

Weszl M, Skaliczki G, Cselenyák A, Kiss L, Major T, Schandl K, Bognár E, Stadler G, Peterbauer A, Csönge L. J Orthop Res. 2012 Mar;30(3):489-96. [abstract]

Cementum protein 1 (CEMP1) induces differentiation by human periodontal ligament cells under three-dimensional culture conditions. 

Hoz L, Romo E, Zeichner-David M, Sanz M, Nuñez J, Gaitán L, Mercado G, Arzate H., Cell Biol Int.2012 Feb 1;36(2):129-36. [Abstract]

NASA-Approved Rotary Bioreactor Enhances Proliferation of Human Epidermal Stem Cells and Supports Formation of 3D Epidermis-Like Structure.

Lei XH, Ning LN, Cao YJ, Liu S, Zhang SB, Qiu ZF, Hu HM, Zhang HS, Liu S, Duan EK.PLoS One. 6(11):e26603; Nov 2011 [Abstract] [Full text] [Full text pdf]

Development of a novel three-dimensional, automatable and integrated bioprocess for the differentiation of embryonic stem cells into pulmonary alveolar cells in a rotating vessel bioreactor system. 

Ismail S, Samadikuchaksaraei A, Bishop A, Polak JM, Mantalaris A.Tissue Eng Part C Methods. Epub Nov 2011 [Abstract]

The simulated microgravity enhances the differentiation of mesenchymal stem cells into neurons.

Chen J, Liu R, Yang Y, Li J, Zhang X, Li J, Wang Z, Ma J. Neurosci Lett.;505(2):171-5. Nov 2011 [Abstract]

Simulated microgravity using a rotary cell culture system promotes chondrogenesis of human adipose-derived mesenchymal stem cells via the p38 MAPK pathway. 

Yu B, Yu D, Cao L, Zhao X, Long T, Liu G, Tang T, Zhu Z. Biochem Biophys Res Commun.;414(2):412-8 Oct 2011 [Abstract]

An epidermal stem cells niche microenvironment created by engineered human amniotic membrane.

Ji SZ, Xiao SC, Luo PF, Huang GF, Wang GY, Zhu SH, Wu MJ, Xia ZF Biomaterials.;32(31):7801-11, Nov 2011 [Abstract]

Enhanced cardiac differentiation of mouse embryonic stem cells by use of the slow-turning, lateral vessel (STLV) bioreactor.

Rungarunlert S, Klincumhom N, Bock I, Nemes C, Techakumphu M, Pirity MK, Dinnyes A. Biotechnol Lett. 2011 Aug;33(8):1565-73, 2011 [Abstract]

Reconstitution of hepatic tissue architectures from fetal liver cells obtained from a three-dimensional culture with a rotating wall vessel bioreactor.

Ishikawa M, Sekine K, Okamura A, Zheng YW, Ueno Y, Koike N, Tanaka J, Taniguchi H. J Biosci Bioeng. 111(6):711-8. June 2011 [Abstract]

Enhancement of matrix production and cell proliferation in human annulus cells under bioreactor culture.

Yang X, Wang D, Hao J, Gong M, Arlet V, Balian G, Shen FH, Li XJ. Tissue Eng Part A.; 17(11-12):1595-603, June 2011 [Abstract]

Computational modeling for the optimization of a cardiogenic 3D bioprocess of encapsulated embryonic stem cells.

Consolo F, Bariani C, Mantalaris A, Montevecchi F, Redaelli A, Morbiducci U. Biomech Model Mechanobiol., Apr 2011 [Abstract]

Chondrocytes and bone marrow-derived mesenchymal stem cells undergoing chondrogenesis in agarose hydrogels of solid and channelled architectures respond differentially to dynamic culture conditions.

Sheehy EJ, Buckley CT, Kelly DJ., J Tissue Eng Regen Med. Epub Jan 2011 [Abstract]

Simultaneous expansion and harvest of hematopoietic stem cells and mesenchymal stem cells derived from umbilical cord blood.

Kedong S, Xiubo F, Tianqing L, Macedo HM, LiLi J, Meiyun F, Fangxin S, Xuehu M, Zhanfeng C 21(12):3183-93, 2010 [Abstract]

Unique differentiation profile of mouse embryonic stem cells in rotary and stirred tank bioreactors.

Fridley KM, Fernandez I, Li MT, Kettlewell RB, Roy K. Tissue Eng Part A; 16(11):3285-98, 2010 [Abstract]

Influence of acellular natural lung matrix on murine embryonic stem cell differentiation and tissue formation.

Cortiella J, Niles J, Cantu A, Brettler A, Pham A, Vargas G, Winston S, Wang J, Walls S, Nichols JE.Tissue Eng Part A. 16(8):2565-80, 2010 [Abstract]

NASA approved rotary bioreactor enhances proliferation and osteogenesis of human periodontal ligament stem cells.
Li S, Ma Z, Niu Z, Qian H, Xuan D, Hou R, Ni L.Stem Cells Dev. 18:1273-82, 2009 [Abstract]

The use of murine embryonic stem cells, alginate encapsulation, and rotary microgravity bioreactor in bone tissue engineering.

Hwang YS, Cho J, Tay F, Heng JY, Ho R, Kazarian SG, Williams DR, Boccaccini AR, Polak JM, Mantalaris A. Biomaterials 30: 499-507, 2008 [Abstract]

Reconstruction of Functional Cortical-Like Tissues from Neural Stem and Progenitor Cells.

Ma W, Tavakoli T, Chen S, Maric D, Liu JL, O'Shaughnessy TJ. Tissue Eng Part A 14: 1687-1697, 2008 [Abstract]

Improvement of culture conditions of human embryoid bodies using a controlled perfused and dialyzed bioreactor system.

 Come J, Nissan X, Aubry L, Tournois J, Girard M, Perrier AL, Peschanski M, Cailleret M. Tissue Eng Part C Methods 14: 289-298, 2008 [Abstract]

Engineering of Functional Cartilage Tissue Using Stem Cells from Synovial Lining: A Preliminary Study.

Pei M, He F, Kish VL, Vunjak-Novakovic G. Clin Orthop Relat Res 466: 1880-1889, 2008 [Abstract] [Full Text] [Full Text pdf]

Integrated 3-Dimensional Expansion and Osteogenic Differentiation of Murine Embryonic Stem Cells.

Randle WL, Cha JM, Hwang YS, Chan KL, Kazarian SG, Polak JM, Mantalaris A.; Tissue Eng 13: 2957-2970, 2007 [Abstract]

Cell-cell and cell-extracellular matrix interactions regulate embryonic stem cell differentiation.

Chen SS, Fitzgerald W, Zimmerberg J, Kleinman HK, Margolis L.; Stem Cells 25: 553-561, 2007 [Abstract] [Full Text] [Full Text pdf]

Embryonic-like stem cells from umbilical cord blood and potential for neural modeling.

McGuckin C, Forraz N, Baradez MO, Basford C, Dickinson AM, Navran S, Hartgerink JD.; Acta Neurobiol 66: 321-329, 2006 [Abstract] [Full Text pdf]

Creation of engineered cardiac tissue in vitro from mouse embryonic stem cells.

Guo XM, Zhao YS, Chang HX, Wang CY, Ling-Ling E, Zhang XA, Duan CM, Dong LZ, Jiang H, Li J, Song Y, Yang XJ.; Circulation 113 :2229-2237, 2006. [Abstract] [Full Text] [Full Text pdf]

Bioreactor Expansion of Human Bone Marrow Mesenchymal Stem Cells.

Chen X, Xu H, Wan C, McCaigue M, Li G.;  Stem Cells 24: 2052-2059, 2006 [Abstract] [Full Text] [Full Text pdf]

Production of stem cells with embryonic characteristics from human umbilical cord blood.

McGuckin CP, Forraz N, Baradez MO, Navran S, Zhao J, Urban R, Tilton R, Denner L: Cell Prolif 38: 245-255, 2005. [Abstract]

Scalable production of embryoid bodies with the rotary cell culture system.

Wang XL, Wang CY, Yu XJ, Zhao YS, Li J, Duan CM, Guo XM:Sheng Li Xue Bao. 57:486-492, 2005. [Abstract in English] Article in Chinese

Modeled Microgravity Disrupts Collagen I/integrin Signaling During Osteoblastic Differentiation of Human Mesenchymal Stem Cells.

Meyers VE, Zayzafoon M, Gonda SR, Gathings WE, McDonald JM: J Cell Biochem. 93: 697-707, 2004. [Abstract]

Complex Extracellular Matrices Promote Tissue-specific Stem Cell Differentiation.

Philp D, Chen SS, Fitzgerald W, Orenstein J, Margolis L, Kleinman HK: Stem Cells 23: 288-296, 2005. [Abstract] [Full Text] [Full Text pdf]

Bioreactor Cultivation Enhances NTEB Formation and Differentiation of NTES Cells into Cardiomyocytes.

Lu S, Liu S, He W, Duan C, Li Y, Liu Z, Hao T, Wang Y, Li D, Wang C, Gao S: Cloning Stem Cells 10:363-370, 2008 [Abstract]

Neural Stem Cell Differentiation in a Cell-collagen-bioreactor Culture System.

Lin HJ, O’Shaughnessy TJ, Kelly J, Ma W: Dev Brain Res. 153: 163-173, 2004 [Abstract]

Bioreactor Cultivation Enhances the Efficiency of Human Embryoid Body (hEB) Formation and Differentiation.

Gerecht-Nir S, Cohen S, Itskovitz-Eldor J: Biotechnology and Bioengineering : 86: 493-502, 2004. [Abstract]

 Modeled Microgravity Inhibits Osteogenic Differentiation of Human Mesenchymal Stem Cells and Increases Adipogenesis.

Zayzafoon M, Gathings WE, McDonald JM; Endocrinology: 145 2421-2432, 2004. [Abstract][Full Text] [Full Text pdf]

Rhythmicity of Engraftment and Altered Cell Cycle Kinetics of Cytokine-Cultured Murine Marrow in Simulated Microgravity Compared With Static Cultures.

Colvin GA, Lambert JF, Carlson JE, McAuliffe CI, Abedi M, Quesenberry PJ: In Vitro Cell Dev Bio Anim 38: 343-351, 2002. [Abstract]

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