Providing Quality 3D Cell Culture Systems for
Tissue Engineering and Stem Cell Culture Applications

Signalling


Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions.

Barrila J, Radtke AL, Crabbé A, Sarker SF, Herbst-Kralovetz MM, Ott CM, Nickerson CA. Nat Rev Microbiol. 2010 Nov;8(11):791-801 [abstract]

Interaction of SDF-1alpha and CXCR4 plays an important role in pulmonary cellular infiltration in differentiation syndrome.

Zhou J, Hu L, Cui Z, Jiang X, Wang G, Krissansen GW, Sun X. Int J Hematol 91:293-302, 2010 [Abstract]

Analysis of Interactions of Salmonella type three secretion mutants with 3-D intestinal epithelial cells.

Radtke AL, Wilson JW, Sarker S, Nickerson CA. PLoS One 29;5:e15750, 2010 [abstract]

The expression of growth factors and their receptors in retinal and endothelial cells cocultured in the rotating bioreactor.

Kumar R, Harris-Hooker S, Sanford GL. Ethn Dis 18(2 Suppl): S2-44-50, 2008 [Abstract]

Simulated Microgravity Impairs Leukemic Cell Survival Through Altering VEGFR-2/VEGF-A Signaling Pathway

Vincent L, Avancena P, Cheng J, Rafii S, Rabbany S,:Annals of Biomedical Engineering, 33: 1405-1410, 2005 [Abstract]

Low-Shear Modeled Microgravity: A Global Environmental Regulatory Signal Affecting Bacterial Gene Expression, Physiology, and Pathogenesis.

Nickerson CA, Ott CM, Wilson JW, Ramamurthy R, LeBlanc CL,et al.: Journal of Microbiological Methods 54 1-11, 2003. [Abstract]

Tri-dimensional Prostate Cell Cultures in Simulated Microgravity and Induced Changes in Lipid Second Messengers and Signal Transduction.

Clejan S, O’Connor K and Rosenweig N: J Cell Mol Med 5:60-73, 2001. [Abstract]

Selected Contribution: PKC Activation Inhibits Ca(2+) Signaling in Tracheal Epithelial Cells Kept in Simulated Microgravity.

Felix JA, Dirksen ER, Woodruff ML: J Appl Physiol 89: 2855-2864, 2000. [Abstract][Full Text] [Full Text pdf]

Mechanical Stimulation Initiates Intercellular Ca2+ Signaling in Intact Tracheal Epithelium Maintained Under Normal Gravity and Simulated Microgravity.
Felix JA, Chaban VV, Woodruff ML, Dirksen ER:  Am J Respir Cell Mol Biol 18: 602-610, 1998 [Abstract][Full Text] [Full Text pdf]