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Bibliography
Last Updated: 1.31.07

Choose a category below or view the entire list of Rotary Cell Culture System research articles and abstract references.

You can also download the bibliogrpahy as a PDF.

Newest Releases

Ward NE, Pellis NR, Risin SA, Risin D. Gene expression alterations in activated human T-cells induced by modeled microgravity. J. Cell. Biochem. 99: 1187-1202, 2006 [ View Abstract ]

Taga M, Yamauchi K, Odle J, Furian L, Sundaresan A, Ramesh GT, Pellis NR, Andrassy RJ, Kulkarni AD. Melanoma growth and tumorigenicity in models of microgravity. Aviat. Space Environ. Med. 77: 1113-1116, 2006 [ View Abstract ]

Ohyabu Y, Kida N, Kojima H, Taguchi T, Tanaka J, Uemura T. Cartilaginous tissue formation from bone marrow using rotating wall vessel (RWV) bioreactor. Biotechnol. Bioeng. 95: 1003-1008, 2006 [ View Abstract ]

Marolt D, Augst A, Freed LE, Vepari C, Fajardo R, Patel N, Gray M, Farley M, Kaplan D, Vunjak-Novakovic G. Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds and rotating bioreactors. Biomaterials 27: 6138-6149, 2006 [ View Abstract ]

Smith YC, Grande KK, Rasmussen SB, O’Brien AD. Novel three-dimensional organoid model for evaluation of the interaction of uropathologenic Escherichia coli with terminally differentiated human urothelial cells. Infect. Immun. 74: 750-757, 2006 [ View Adbstract ]

Lynch SV, Mukundakrishnan K, Benoit MR, Ayyaswamy PS, Matin A. Escherichia coli biofilms formed under low-shear modeled microgravity in a ground-based system. Appl. Environ. Microbiol. 72: 7701-7710, 2006 [ View Abstract ]

Rucci N, Rufo A, Alamanou M, Teti A. Modeled microgravity stimulates osteoclastogenesis and bone resorption by increasing osteoblast RANK/OPG ratio. J. Cell. Biochem. 100: 464-473, 2007 [ View Abstract ]

Cao YJ, Fan XJ, Shen Z, Ma BH, Duan EK. Nitric oxide affects preimplantation embryonic development in a rotating wall vessel bioreactor simulating microgravity. Cell Biol. Int. 31: 24-29, 2007 [ View Abstract ]

Waters SL, Cummins LJ, Shakesheff KM, Rose FR. Tissue growth in a rotating bioreactor. Part I: mechanical stability. Math. Med. Biol. 23: 311-337, 2006 [ View Abstract ]

Song K, Yang Z, Liu T, Zhi W, Li X, Deng L, Cui Z, Ma X. Fabrication and detection of tissue-engineered bones with bio-derived scaffolds in a rotating bioreactor. Biotechnol. Appl. Biochem. 45(pt 2): 65-74, 2006 [ View Abstract ]

    Marsano A ,Wendt D ,Raiteri R ,Gottardi R ,Stolz M ,Wirz D, Daniels AU ,Salter D s,Jakob M ,Quinn TM ,Martin I. Use of hydrodynamic forces to engineer cartilaginous tissues resembling the non-uniform structure and function of meniscus. Biomaterials 27: 5927-5934, 2006 [ View Abstract ]

    Marsano A ,Wendt D ,Quinn TM ,Sims TJ ,Farhadi J ,Jakob M ,
    Heberer M ,Martin I . Bi-zonal cartilaginous tissues engineered in a rotary cell culture system. Biorheology 43: 553-560, 2006 [ View Abstract ]

    Ju ZH ,Liu TQ ,Ma XH ,Cui ZF . Numerical simulation of microcarrier motion in a rotating wall vessel bioreactor. Biomed Environ Sci 19: 163-168, 2006 [ View Abstract ]

    Luca G ,Calvitti M ,Nastruzzi C ,Macchiarulo G ,Becchetti E , Neri LM ,Capitani S ,Basta G ,Brunetti P ,Calafiore R ,Cameron DF Effects of simulated microgravity on the morphology and function of neonatal porcine cell clusters cultured with and without Sertoli cells. Cell Transplant 15: 55-65, 2006 [ View Abstract ]

    Purevdorj-Gage B ,Sheehan KB, Hyman LE. Effects of low-shear modeled microgravity on cell function, gene expression, and phenotype in Saccharomyces cerevisiae. Appl Environ Microbiol 72: 4569-4575 [ View Abstract ]

    Bruno S ,Bussolati B ,Scacciatella P ,Marra S ,Sanavio F , Tarella C ,Camussi G . Combined administration of G-CSF and GM-CSF stimulates monocyte-derived pro-angiogenic cells in patients with acute myocardial infarction.
    Cytokine 34: 56-65, 2006 [ View Abstract ]

    Maier JA . Impact of simulated microgravity on cell cycle control and cytokine release by U937 cells. Int J Immunopathol Pharmacol 19: 279-286, 2006 [ View Abstract ]

    Chen X ,Xu H ,Wan C ,McCaigue M ,Li G . Bioreactor expansion of human adult bone marrow-derived mesenchymal stem cells. Stem Cells 24: 2052-2059, 2006 [ View Abstract ]

    Wang X ,Wei G ,Yu W ,Zhao Y ,Yu X ,Ma X . Scalable producing embryoid bodies by rotary cell culture system and constructing engineered cardiac tissue with ES-derived cardiomyocytes in vitro. Biotechnol Prog 22: 811-818, 2006 [ View Abstract ]

    Roberts JE ,Kukielczak BM ,Chignell CF ,Sik BH ,Hu DN ,Principato MA . Simulated microgravity induced damage in human retinal pigment epithelial cells. Mol Vis 12: 633-638, 2006 [ View Abstract ]

    Xie Y ,Wang F ,Zhong W ,Puscheck E ,Shen H ,Rappolee DA . Shear stress induces preimplantation embryo death that is delayed by the zona pellucida and associated with stress-activated protein kinase-mediated apoptosis. Biol Reprod 75: 45-55, 2006 [ View Abstract ]

    Di Loreto S ,Sebastiani P ,Benedetti E ,Zimmitti V ,Caracciolo V , Amicarelli F ,Cimini A ,Adorno D . Transient maintenance in bioreactor improves health of neuronal cells. In Vitro Cell Dev Biol Anim 42: 134-142, 2006 [ View Abstract ]

    Manley P ,Lelkes PI . A novel real-time system to monitor cell aggregation and trajectories in rotating wall vessel bioreactors. J Biotechnol 125: 416-424, 2006 [ View Abstract ]

    Frye CA ,Patrick CW . Three-dimensional adipose tissue model using low shear bioreactors. In Vitro Cell Dev Biol Anim 42: 109-114, 2006 [ View Abstract ]

    zu Bentrup KH, Ramamurthy R, Ott CM, Emami K, Nelman-Gonzalez M, Wilson JW, Richter EG, Goodwin TJ, Alexander JS, Pierson DL, Pellis N, Buchanan KL, Nickerson CA. Three-dimensional organotypic models of human colonic epithelium to study the early stages of enteric salmonellosis. Microbes Infect 8: 1813-1825, 2006 [ View Abstract ]

     

Fluid Mechanical Principles of RCCS

    1. Lappa, M. Fluids, Materials, and Microgravity: Numerical Techniques and Insights into the Physics. Naples, Italy: Elsevier Science Oxford, 2004.

    2. Botchwey EA, Pollack SR, Levine EM, Johnston ED, Leurencin CT: Quantitative Analysis of Three-Dimensional Fluid Flow in Rotating Bioreactors for Tissue Engineering. J Biomed Mater Res 69(A): 205-15, 2004. [ View Abstract ]

    3. Lappa M: Organic Tissues in Rotating Bioreactors: Fluid-Mechanical Aspects, Dynamic Growth Models, and Morphological Evolutions. Biotechnol Bioeng. Dec 5; 84(5): 518-532, 2003. [ View Abstract ]

    4. Hammond TG, and Hammond JM: Optimized Suspension Culture: The Rotating-Wall Vessel. Am J Physiol Renal Physiol 281: F12-F25, 2001. [ View Abstract ]

    5. Rivera-Solorio I, Kleis SJ. Model of the mass transport to the surface of animal cells cultured in a rotating bioreactor operated in micro gravity. Biotechnol Bioeng. 94: 495-504, 2006 [ View Abstract ]

    6. Ju ZH ,Liu TQ ,Ma XH ,Cui ZF . Numerical simulation of microcarrier motion in a rotating wall vessel bioreactor. Biomed Environ Sci 19: 163-168, 2006 [ View Abstract ]

     

General Review Articles

    1. Nickerson CA, Ott CM, Wilson JW, Ramamurthy R, LeBlanc CL,et al.: Low-Shear Modeled Microgravity: A Global Environmental Regulatory Signal Affecting Bacterial Gene Expression, Physiology, and Pathogenesis. Journal of Microbiological Methods 54:1-11, 2003 [ View Abstract ]

    2. Unsworth BR and Lelkes PI: Growing Tissues in Microgravity. Nature Medicine 4: 901-7, 1998.

    3. Duray PH, Hatfill SJ and Pellis NR: Tissue Culture in Microgravity. Science & Medicine, May/June, 45-55, 1997. [ View Abstract ]

Bone

    1. Mukundakrishnan K, Ayyaswamy PS, Risbud M, Hu HH, Shapiro IM: Modeling of Phosphate Ion Transfer to the Surface of Osteoblasts Under Normal Gravity and Simulated Microgravity Conditions. Ann N Y Acad Sci. 1027:85-98, Nov 2004. [ View Abstract ]

    2. Bucaro MA, Fertala J, Adams CS, Steinbeck M, Ayyaswamy P, Mukundakrishnan K, Shapiro IM, Risbud MV: Bone Cell Survival in Microgravity: Evidence That Modeled Microgravity Increases Osteoblast Sensitivity to Apoptogens. Ann N Y Acad Sci 1027:64-73, Nov 2004. [ View Abstract ]

    3. Yu X, Botchwey EA, Levine EM, Pollack SR, Laurencin CT: Bioreactor-based Bone Tissue Engineering: The Influence of Dynamic Flow on Osteoblast Phenotypic Expression and Matrix Mineralization. Proc Natl Acad Sci 101 (31): 11203-8, 2004. [ View Abstract ]

    4. Ontiveros C, Irwin R, Wiseman RW, McCabe LR: Hypoxia Suppresses Runx2 Independent of Modeled Microgravity. J Cell Physiol Aug; 200(2): 169-76, 2004. [ View Abstract ]

    5. Klement BJ, Young QM, George BJ, Nokkaew M: Skeletal Tissue Growth, Differentiation, and Mineralization in the NASA Rotating Wall Vessel. Bone 34: (3) 487-498, 2004. [ View Abstract ]

    6. Torday JS: Parathyroid hormone-related protein is a gravisensor in lung and bone cell biology. Adv Space Research, 32, 1569-76, 2003. [ View Abstract ]

    7. Botchwey EA, Pollack SR, El-Amin S, Levine EM, Tuan RS and Laurencin CT: Human Osteoblast-Like Cells in Three-Dimensional Culture with Fluid Flow. Biorheology 40:299-306, 2003. [ View Abstract ]

    8. Ontiveros C and McCabe LR: Simulated Microgravity Suppresses Osteoblast Phenotype, Runx2 Levels and AP-1 Transactivation . J Cell Biochem 88:427-37, 2003. [ View Abstract ]

    9. Tang K, Dang G and Guo Z: The Effects of Intermittent Hydromechanics on the Differentiation and Function of Bone Marrow Stromal Derived-osteoblasts in Porous Calcium Phosphate Ceramics. Zhonghua Yi Xue Za Zhi 82:665-8, 2002. [ View Abstract ]

    10. Rucci N, Migliaccio S, Zani BM, Taranta A, and Teti A, Characterization of the Osteoblast-like Cell Phenotype Under Microgravity Conditions in the NASA-approved Rotating Wall Vessel Bioreactor (RWV), J Cell Biochem 85:167-79, 2002. [ View Abstract ]

    11. Botchwey EA, Pollack SR, Levine EM and Laurencin CT: Bone Tissue Engineering in a Rotating Bioreactor Using a Microcarrier Matrix System. J Biomed Mater Res 55:242-53, 2001. [ View Abstract ]

    12. Goldstein AS, Juarez TM, Helmke CD and Mikos AG: Effect of Convection on Osteoblastic Cell Growth and Function in Biodegradable Polymer Foam Scaffolds. Biomaterials 22:1279-88, 2001. [ View Abstract ]

    13. Radin S, Ducheyne P, Ayyaswamy PS and Gao H: Surface Transformation of Bioactive Glass in Bioreactors Simulating Microgravity Conditions. Part I: Experimental Study. Biotechnol Bioeng 75:369-78, 2001. [ View Abstract ]

    14. Gao H, Ayyaswamy PS, Ducheyne P, Radin S: Surface Transformation of Bioactive Glass in Bioreactors Simulating Microgravity Conditions: Part II: Numerical Simulations. Biotechnol Bioeng 75:379-85, 2001. [ View Abstract ]

    15. Qiu QQ, Ducheyne P. and Ayyaswamy PS: 3D Bone Tissue Engineered with Bioactive
    Microspheres in Simulated Microgravity. In Vitro Cell Dev Biol Anim 37: 157-165, 2001. [ View Abstract ]

    16. Qiu QQ, Ducheyne P, Ayyaswamy PS: Fabrication, Characterization and Evaluation of Bioceramic Hollow Microspheres Used as Microcarriers for 3-D Bone Tissue Formation in Rotating Bioreactors. Biomaterials 20: 989-1001, 1999. [ View Abstract ]

    17. Granet C, Laroche N, Vico L, Alexandre C, Lafage Proust MH: Rotating-Wall Vessels, Promising Bioreactors for Osteoblastic Cell Culture: Comparison with Other 3D Conditions. Med Biol Eng Comput 36: 513-9, 1998. [ View Abstract ]

    18. Akmal M, Anand A, Anand B, Wiseman M, Goodship AE, Bentley G. The culture of articular chondrocytes in hydrogel constructs within a bioreactor enhances cell proliferation and matrix synthesis. J Bone Joint Surg Br 88: 544-553, 2006 [ View Abstract ]

    19. Song K, Yang Z, Liu T, Zhi W, Li X, Deng L, Cui Z, Ma X. . Biotechnol Appl Biochem May 2006 (Epub ahead of pFabrication and detection of tissue engineering bones with bio-derived scaffolds in a rotating bioreactorrint) [ View Abstract ]

    20. Inac B, Elcin AE, Elcin YM. Osteogenic Induction of Human Periodontal Ligament Fibroblasts Under Two- and Three- Dimensional Culture Conditions. Tissue Eng. 12: 257-266, 2006 [ View Abstract ]

    21. Song K, Yang Z, Liu T, Zhi W, Li X, Deng L, Cui Z, Ma X. Fabrication and detection of tissue-engineered bones with bio-derived scaffolds in a rotating bioreactor. Biotechnol. Appl. Biochem. 45(pt 2): 65-74, 2006 [ View Abstract ]

    22. Rucci N, Rufo A, Alamanou M, Teti A. Modeled microgravity stimulates osteoclastogenesis and bone resorption by increasing osteoblast RANK/OPG ratio. J. Cell. Biochem. 100: 464-473, 2007 [ View Abstract ]

     

Cancer

    1. Song H, David O, Clejan S, Giordano CL, Pappas-Lebeau H, Xu, L, O’Connor KC: Spatial Composition of Prostate Cancer Spheroids in Mixed and Static Cultures. Tissue Eng. 10: 7/8, 1266-1276, 2004. [ View Abstract ]

    2. Moon B, Lee YJ, Battle P, Jessup JM, Raz A, Kim HRC: Galectin-3 Protects Human Breast Carcinoma Cells against Nitric Oxide-Induced Apoptosis: Implication of Galectin-3 Function during Metastasis. Amer. Jour. Path. 159: 3, 1055-1060, 2001. [ View Abstract ]

    3. Song YK, Billiar TR, Lee YJ: Role of Galectin-3 in Breast Cancer Metastasis: Involvement of Nitric Oxide. Amer. Jour. Path. 160: 3, 1069-1075, 2002. [ View Abstract ]

    4. Rhiel MH, Cohen MB, Arnold MA, Murhammer DW: On-line Monitoring of Human Prostate Cancer Cells in a Perfusion Rotating Wall Vessel by Near-Infrared Spectroscopy. Biotechnol Bioeng Jun 30; 86(7): 852-61, 2004. [ View Abstract ]

    5. Green LM, Patel Z, Murray DK, Rightnar S, Burell CG, Gridley DS, Nelson GA: Cytoskeletal and Functional Changes in Bioreactor Assembled Thyroid Tissue Organoids Exposed to Gamma Radiation. J Radiat. Res. 43: S213-S218, 2002. [ View Abstract ]

    6. Winkerwerder JJ, Palechek PL, Reece JS, Saarinen MA, Arnold MA, Cohen MB, Murhammer DW: Evaluating Prostate Cancer Cell Culturing Methods: A Comparison of Cell Morphologies and Metabolic Activity. Oncol.. Rep. Jul/Aug, 783-9, 2003. [ View Abstract ]

    7. Nakamura K, Kuga H, Morisaki T, Baba E, Sato N, Mizumoto K, Sueshi K, Tanaka M, and Katano M: Simulated Microgravity Culture System for a 3-D Carcinoma Tissue Model Biotechniques 33:1068-1076, 2002. [ View Abstract ]

    8. Savary C, Grazziuti ML, Przepiorka D, Tomasovic SP, McIntyre BW, Woodside DG, Pellis NR, Pierson DL, Rex JH: Characteristics of Human Dendritic Cells Generated in a Microgravity Analog Culture System In Vitro Cell Dev Biol Anim Apr;37(4):216-22, 2001. [ View Abstract ]

    9. Rhee HW, Shau HE, Pathak S, Multani AS, Oennanen S, Visakorpi T, and Chung LWK: Permanent Phenotypic and Genotypic Changes of Prostate Cancer Cells Cultured In a Three-Dimensional Rotating-Wall Vessel. In Vitro Cell Dev Biol Anim 37: 127-140, 2001. [ View Abstract ]

    10. Licato LL, Prieto VG, and Grimm EA: A Novel Preclinical Model of Human Malignant Melanoma Utilizing Bioreactor Rotating-Wall Vessels. In Vitro Cell Dev Biol Anim 37: 121-126, 2001. [ View Abstract ]

    11. Jessup JM, Frantz M, Sonmez-Alpan E, Locker J, Skena K, Waller H, Battle P, Nachman A, Bhatti, Weber ME, Thomas DA, Curbeam RL, Baker TL, and Goodwin TJ: Microgravity Culture Reduces Apoptosis and Increases the Differentiation of a Human Colorectal Carcinoma Cell Line, In Vitro Cell Dev Biol 36:367-73, 2000. [ View Abstract ]

    12. Kaeffer B, Bénard C, Lahaye M, Blottiére HM, Cherbut C: Biological Properties of Ulvan, a New Source of Green Seaweed Sulfated Polysaccharides, on Cultured Normal and Cancerous Colonic Epithelial Cells. Planta Med 65:6 527-31, 1999. [ View Abstract ]

    13. O’Connor KC: Three-Dimensional Cultures of Prostatic Cells: Tissue Models for the Development of Novel Anti-Cancer Therapies. Pharmaceutical Research 16: 486-93, 1999. [ View Abstract ]

    14. Rhee H, Chang S, Garner T and Chung L: Three-Dimensional (3-D) Human Prostate Organoid Culture to Study Cell-Cell and Cell-Matrix Interaction: Irreversible Alterations of Prostate Epithelial Tumorigenicity, Growth Responsiveness to Androgen and Estrogen, and Growth Factors in Culture. J Urology 159 (Suppl) 5, 1998.

    15. Goodwin TJ, Prewett TL, Spaulding GF, Becker JL: Three-Dimensional Culture of a Mixed Mullerian Tumor of the Ovary: Expression Of In Vivo Characteristics. In Vitro Cell Dev Biol Anim 33: 366-74, 1997. [ View Abstract ]

    16. Chopra V, Dinh TV, and Hannigan EV: Three-Dimensional Endothelial-Tumor Epithelial Cell Interactions in Human Cervical Cancers. In Vitro Cell Dev Biol Anim 33: 432-42, 1997. [ View Abstract ]

    17. Ingram M, Techy GB, Saroufeem R, Yazan O, Narayan KS, Goodwin TJ and Spaulding GF: Three-Dimensional Growth Patterns of Various Human Tumor Cell Lines in Simulated Microgravity of a NASA Bioreactor. In Vitro Cell Dev Biol Anim 33: 459-66, 1997. [ View Abstract ]

    18. Zhau HE, Goodwin TJ, Shi-Ming Chang, Baker TL and Chung LWK: Establishment of Three-Dimensional Human Prostate Organoid Coculture under Microgravity-Simulated Conditions: Evaluation of Androgen-Induced Growth and PSA Expression. In Vitro Cell Dev Bio Anim 33: 375-80, 1997. [ View Abstract ]

    19. O’Connor KC, Enmon RM, Dotson RS, Primavera AC and Clejan S: Characterization of Autocrine Growth Factors, Their Receptors and Extracellular Matrix Present in Three-Dimensional Cultures of DU 145 Prostate Carcinoma Cells Grown in Simulated Microgravity. Tissue Engineering 3: 161- 171 , 1997.

    20. Jessup JM, Brown D, Fitzgerald W, Ford RD, Nachman A, Goodwin TJ and Spaulding G: Induction of Carcinoembryonic Antigen Expression in a Three-Dimensional Culture System. In Vitro Cell Dev Biol Anim 33: 352-7, 1997. [ View Abstract ]

    21. Becker JL, Papenhausen PR and Widen RH: Cytogenetic, Morphologic and Oncogene Analysis of a Cell Line Derived from a Heterologous Mixed Mullerian Tumor of the Ovary. In Vitro Cell Dev Biol Anim 33: 325-31, 1997. [ View Abstract ]

    22. Clejan S, O’Conner KC, Cowger NL, Cheles MK, Haque S and Primavera AC: Effects of Simulated Microgravity on DU 145 Human Prostate Carcinoma Cells. Biotechnol Bioeng 50: 587-97, 1996. [ View Abstract ]

    23. Jessup JM, Goodwin TJ, Spaulding GF: Prospects for Use of Microgravity-Based Bioreactors to Study Three Dimensional Host-Tumor Interactions in Human Neoplasia. J Cell Biochem 51: 290-300, 1993. [ View Abstract ]

    24. Becker JL, Prewett TL, Spaulding GF, Goodwin TJ: Three-Dimensional Growth and Differentiation of Ovarian Tumor Cell Line in High Aspect Rotating Wall Vessel. Morphologic and Embryologic Considerations J Cell Biochem 51: 283-9, 1993. [ View Abstract ]

    25. Prewett TL, Goodwin TJ, Spaulding GF: Three Dimensional Modeling of T-24 Human Bladder Carcinoma Cell Line: A New Simulated Microgravity Vessel. J Tissue Culture Methods. 15: 29-36,1993.

    26. Goodwin TJ, Jessup JM, Wolf DA: Morphological Differentiation of Colon Carcinoma Cell Lines HT-29 and HT-29KM in Rotating Wall Vessels. In Vitro Cell Div Biol 28A:1 47-60, 1992. [ View Abstract ]

    27. Goodwin TJ, Prewett TL, Spaulding GF, Widen RH, Becker JL: A Model for Culture of Primary Breast Carcinoma Tissues in Rotating Wall Vessels (RWV). Johnson Space Center, Biotechnology Group and KRUG Life Sciences, Houston, Tx, Dept. of Medical Microbiology and Immunology and Dept. of Ob/Gyn, University of South Florida, Tampa, FL.

    Taga M, Yamauchi K, Odle J, Furian L, Sundaresan A, Ramesh GT, Pellis NR, Andrassy RJ, Kulkarni AD. Melanoma growth and tumorigenicity in models of microgravity. Aviat. Space Environ. Med. 77: 1113-1116, 2006 [ View Abstract ]

Cartliage / Chondrocytes

    1. Tognana, E., Padera, R.F., Chen, F., Vunjak-Novakovic, G., Freed, L.E): Development and remodeling of engineered cartilage-explant composites in vitro and in vivo. Osteoarthritis and Cartilage (2005) 13(10) 896-905. [ View Abstract ]

    2. Tognana, E., Chen, F., Padera, R.F., Leddy, H.A, Christensen, S.E., Guilak, F., Vunjak-Novakovic, G., Freed, L.E: Adjacent Tissue (Cartilage, Bone) Affect the Functional Integration of Engineered Calf Cartilage in vitro. Osteoarthritis and Cartilage 13(2) 129-138. (2005) [ View Abstract ]

    3. Murray H.E., Padget, M.B, Downing, R.: Preservation of glucose responsiveness in human islets maintained in a rotational cell culture system. Molecular and Cellular Endocrinology 238: 39-49, 2005

    4. Hu JC, Athanasiou KA: Low-density Cultures of Bovine Chondrocytes: Effects of Scaffold Material and Culture System. Biomaterials 26(14):2001-12, May 2005. [ View Abstract ]

    5. Marlovits S, Tichy B, Truppe M, Gruber D, Vecsei V. Chondrogenesis of Aged Human Articular Cartilage in a Scaffold-Free Bioreactor. Tissue Eng. Vol. 9, No.6, 1215-1226, 2003. [ View Abstract ]

    6. Marlovits S, Tichy B, Truppe M, Gruber D, Schlegel W. Collagen Expression in Tissue Engineered Cartilage of Aged Human Articular Chondrocytes in a Rotating Bioreactor: Int. Jour. Artificial Organs 26: 319-330, Apr. 2003. [ View Abstract ]

    7. Darling EM, Athanasiou KA. Articular Cartilage Bioreactors and Bioprocesses. Tissue Eng. Vol. 9, No. 1, 9-26, 2003. [ View Abstract ]

    8. Pei M, Solchaga LA, Seidel J, Zenf L. Vunjak-Novakovic G, Caplan AI, Freed LE. Bioreactors Mediate the Effectiveness of Tissue Engineering Scaffolds: FASEB J 16:1691-4, 2002. [ View Abstract ]

    9. Pei M, Solchaga LA, Seidel J, Zenf L. Vunjak-Novakovic G, Caplan AI, Freed LE Ming Pei*, Luis A. Solchaga: Bioreactors mediate the effectiveness of tissue engineering scaffolds: The FASEB Journal express article 10.1096/fj.02-0083fje. Published online August 7, 2002. [ View Abstract ]

    10. Pei M, .Seidel J, G.Vunjak-Novakovic,and.Freed L.E. Growth factors for sequential cellular de-and re-di .erentiation in tissue engineering: Biochemical and Biophysical Research Communications 294, 149-154, 2002 [ View Abstract ]

    11. Vunjak-Novakovic G, Obradovic B, Martin I, Freed LE: Bioreactor Studies of Native and Tissue Engineered Cartilage. Biorheology 39:259-68, 2002. [ View Abstract ]

    12. Koch RJ, Gorti GK: Tissue Engineering with Chondrocytes, Facial Plast Surg 18:59-68, 2002. [ View Abstract ]

    13. Gooch KJ, Blunk T, Courter DL, Sieminski AL, Bursac PM, Vunjak-Novakovic G and Freed LE: IGF-I and Mechanical Environment Interact to Modulate Engineered Cartilage Development. Biochem Biophys Res Commun 286:909-15, 2001. [ View Abstract ]

    14. Martin I, Obradovic B, Treppo S, Grodzinsky AJ, Langer R, Freed LE, and Vunjak-Novakovic G: Modulation of The Mechanical Properties of Tissue Engineered Cartilage. Biorheology 37:141-7, 2000. [ View Abstract ]

    15. Falsafi S and Koch RJ: Growth of Tissue-Engineered Human Nasoseptal Cartilage in Simulated Microgravity. Arch Otolaryngol Head Neck Surg 126:759-65, 2000. [ View Abstract ]

    16. Vunjak-Novakovic G, Martin I, Obradovic B, Treppo S, Grodzinsky AJ, Langer R, and Freed L: Bioreactor Cultivation Conditions Modulate the Composition and Mechanical Properties of Tissue-Engineered Cartilage. J Orthop Res 17: 130-8, 1999. [ View Abstract ]

    17. Obradovic B, Carrier R, Vunjak-Novakovic G and Freed LE: Gas Exchange is Essential for Bioreactor Cultivation of Tissue Engineered Cartilage. Biotechnol Bioeng 63: 197-205, 1999. [ View Abstract ]

    18. Freed L, Martin I and Vunjak-Novakovic G: Frontiers in Tissue Engineering –In Vitro Modulation of Chondrogenesis. Clinical Orthopedics and Related Research 367S:S46-S58, 1999. [ View Abstract ]

    19. Freed L. et al: Chondrogenesis in a Cell-Polymer Bioreactor system. Exp Cell Res 240: 58-65, 1998. [ View Abstract ]

    20. Riesle J, Hollander AP, Langer R, Freed LE, and Vunjak-Novakovic G: Collagen in Tissue-Engineered Cartilage: Types Structure, and Crosslinks. J of Cell Biochem 71: 313-27, 1998. [ View Abstract ]

    21. Baker TL and Goodwin TJ: Three Dimensional Culture of Bovine Chondrocytes in Rotating-Wall Vessels. In vitro Cell Dev Biol Anim 33: 352-7, 1997. [ View Abstract ]

    22. Duke PJ, Daane E, Arizpe J and Montufar-Solis D: Chondrogenesis in Aggregates of Embryonic Limb Cells Grown in a Rotating Wall Vessel. Adv. Space Research 17: 289-93, 1996. [ View Abstract ]

    23. Freed LE and Vunjak-Novakovic G: Cultivation of Cell-Polymer Tissue Constructs in Simulated Microgravity. Biotechnol Bioeng 46: 306-13,1995. [ View Abstract ]

    24. Duke PJ, Daane EL, Montufar-Solis D: Studies of Chondrogenesis in Rotating Systems J Cell Biochem 51: 274-82,1993. [ View Abstract ]

    25. Freed LE, Vunjak-Novakovic G and Langer R: Cultivation of Cell-Polymer Cartilage Implants in Bioreactors. J Cell Biochem 51: 257-64, 1993. [ View Abstract ]

    26. Marsano A ,Wendt D ,Raiteri R ,Gottardi R ,Stolz M ,Wirz D, Daniels AU ,Salter D s,Jakob M ,Quinn TM ,Martin I. Use of hydrodynamic forces to engineer cartilaginous tissues resembling the non-uniform structure and function of meniscus. Biomaterials 27: 5927-5934, 2006 [ View Abstract ]

    27. Marsano A ,Wendt D ,Quinn TM ,Sims TJ ,Farhadi J ,Jakob M ,
    Heberer M ,Martin I . Bi-zonal cartilaginous tissues engineered in a rotary cell culture system. Biorheology 43: 553-560, 2006 [ View Abstract ]

    28. Ohyabu Y, Kida N, Kojima H, Taguchi T, Tanaka J, Uemura T. Cartilaginous tissue formation from bone marrow using rotating wall vessel (RWV) bioreactor. Biotechnol. Bioeng. 95: 1003-1008, 2006 [ View Abstract ]

    29. Marolt D, Augst A, Freed LE, Vepari C, Fajardo R, Patel N, Gray M, Farley M, Kaplan D, Vunjak-Novakovic G. Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds and rotating bioreactors. Biomaterials 27: 6138-6149, 2006 [ View Abstract ]

     

Heart / Cardio-Vascular

    95. [Abstract in English, Article in Chinese]
    Yang F, Li YH, Nie JL: [Pilot Study of Neonatal Rat Cardiac Myocytes Cultured for Three-Dimensional Modeling in Simulated Microgravity]. Zhongguo Xiu Fu Chong Juan Wai Ke Za Zhi Mar; 18(2):119-22, 2004. [ View Abstract ]

    96. Morin JP, Preterre D, Keravec V, Thuillez C: Rotating Wall Vessel as a New In Vitro Shear Stress Generation System: Application to Rat Coronary Endothelial Cell Cultures. Cell Biol Toxicol. 19(4), 227-42, 2003. [ View Abstract ]

    97. Bursac N, Papadaki M, White JA, Eisenberg SR, Vunjak-Novakovic G, Freed L: Cultivation in Rotating Bioreactors Promotes Maintenance of Cardiac Myocyte Electrophysiology and Molecular properties. Tissue Eng. Vol. 9, No.6, 1243-1253, 2003. [ View Abstract ]

    98. Van Luyn MA, Tio RA, Gallego y van Seijen XJ, Plantinga JA, de Leij LFMH, DeJongste ML, van Wachem PB: Cardiac Tissue Engineering: Characteristics of in Unison Contracting Two- and Three-dimensional Neonatal Rat Ventricle Cell (Co)-Cultures. Biomaterials 23: 4793-4801, 2002.

    [Article in Chinese, Abstract in English]
    Liu X, Wang CY, Guo XM, OuYang WQ: Experimental Study of Cardiac Muscle Tissue Engineering in Bioreactor. Zhongguo Yi Xue Yuan Xue Bao Feb., 7-12, 2003. [ View Abstract ]

    99. Sutherland FW, Perry TE, Nassen BA, Wang J, Kaushal S, Guleserian KJ, Martin DP, Vacanti JP and Mayer JE: Advances in the Mechanisms of Cell Delivery to Cardiovascular Scaffolds: Comparison of Two Rotating Cell Culture Systems. ASAIO J 48:346-9, 2002. [ View Abstract ]

    100. Papadaki M, Bursac N, Langer R, Merok J, Vunjak-Novakovic G, Freed LE: Tissue Engineering of Functional Cardiac-Muscle: Molecular, Structural, and Electrophysiological Studies. Am J Physiol Heart Physiol 280:H168-78, 2001. [ View Abstract ]

    101. Lwigale PY, Thurmond JE, Norton WN, Spooner BS, Wiens DJ: Simulated Microgravity and Hypergravity Attenuate Heart Tissue Development in Explant Culture. Cells Tissues Organs 167:2-3 171-83, 2000. [ View Abstract ]

    102. Carrier RL, Papadaki M, Rupnick M, Schoen F, Bursac N, Langer R, Freed LE, Vunjak-Novakovic G: Cardiac Tissue Engineering: Cell Seeding, Cultivation Parameters, and Tissue Construct Characterization. Biotechnol Bioeng 64: 580-9, 1999. [ View Abstract ]

    103. Bursac N, Papadaki M,Cohen AJ, Schoen FJ, Eisenberg SR, Carrier R, Vunjak-Novakovic G, Freed LE: Cardiac Muscle Tissue Engineering: Toward an In Vitro Model for Electrophysiological Studies. Am J Physiol 277: Pt 2 H433-44, 1999. [ View Abstract ]

    104. Akins RE, Schroedl NA, Gonda SR and Hartzell CR: Neonatal Rat Heart Cells Cultured in Simulated Microgravity. In Vitro Cell Dev Biol Anim 33: 337-43, 1997. [ View Abstract ]

    104a. Cotrupi S, Ranzani D, Maier JA. Impact of modeled microgravity on microvascular endothelial cells. Biochim Biophys Acta 1746(2):163-168, 2005. [ View Abstract ]

Hematopoietic System

    1. Plett PA, Abonour R, Frankovitz SM, Orschell CM: Impact of Modeled Microgravity on Migration, Differentiation, and Cell Cycle Control of Primitive Human Hematopoietic Progenitor Cells. Experimental Hematology 32: 773-781, 2004. [ View Abstract ]

    2. Bakos A, Varkonyi A, Minarovits J, Batkai L: Effect of Simulated Microgravity on the Production of IL-12 by PBMC’s. J Gravit Physiol. 9(1): 293-4, 2002. [ View Abstract ]

    3. Kaeffer B, Trubuil A, Kervrann C, Pardini L, Cherbut C: Three-Dimensional Binding of Epidermal Growth Factor Peptides in Colonic Tissues Produced From Rotating Bioreactor. In Vitro Cell Dev Biol Anim 38:436-9, 2002. [ View Abstract ]

    4. Plett PA, Frankovitz SM, Abonour R, Orschell-Traycoff CM: Proliferation of Human Hematopoietic Bone Marrow Cells in Simulated Microgravity. In Vitro Cell Dev Biol Anim 37:73-8, 2001. [ View Abstract ]

    5. Sytkowski AJ and Davis KL: Erythroid Cell Growth and Differentiation In Vitro in the Simulated Microgravity Environment of the NASA Rotating Wall Vessel Bioreactor. In Vitro Cell Dev Biol Anim 37:79-83, 2001. [ View Abstract ]

    6. Hughes JH and Long JP: Simulated Microgravity Impairs Respiratory Burst Activity in Human Promyelocytic Cells. In Vitro Cell Dev Biol Anim 37:209-15, 2001. [ View Abstract ]

    7. Licato LL, Grimm EA: Multiple Interleukin-2 Signaling Pathways Differentially Regulated by Microgravity. Immunopharmacology 44:3 273-9, 1999. [ View Abstract ]

    8. Simons DM, Gardner EM, Lelkes PI. Dynamic culture in a rotating-wall vessel bioreactor differentially inhibits murine T-lymphocyte activation by mitogenic stimuli upon return to static conditions in a time-dependent manner. J Appl Physiol 100: 1287-1292, 2006 [ View Abstract ]

    9. Ritz BW, Lelkes PI, Gardner EM Functional recovery of peripheral blood mononuclear cells in modeled microgravity. FASEB J. 20: 305-307, 2006 [ View Abstract ]

    10. Bruno S ,Bussolati B ,Scacciatella P ,Marra S ,Sanavio F , Tarella C ,Camussi G . Combined administration of G-CSF and GM-CSF stimulates monocyte-derived pro-angiogenic cells in patients with acute myocardial infarction.
    Cytokine 34: 56-65, 2006 [ View Abstract ]

    11. Maier JA . Impact of simulated microgravity on cell cycle control and cytokine release by U937 cells. Int J Immunopathol Pharmacol 19: 279-286, 2006 [ View Abstract ]

    12. Ward NE, Pellis NR, Risin SA, Risin D. Gene expression alterations in activated human T-cells induced by modeled microgravity. J. Cell. Biochem. 99: 1187-1202, 2006 [ View Abstract ]

     

Insect

    1. Joosten CE, Shuler ML: Effect of Culture Conditions on the Degree of Sialylation of a Recombinant Glycoprotein Expressed in Insect Cells. Biotechnol. Prog. 19; 739-749, 2003. [ View Abstract ]

    2. Saarinen MA and Murhammer DW: Culture in the Rotating-Wall Vessel Affects Recombinant Protein Production Capability of Two Insect Cell Lines in Different Manners. In Vitro Cell Dev Biol Anim 36:362-6, 2000. [ View Abstract ]

    3. Park JH, Lee JM, Park IS: Production of Recombinant Endostatin from Stably Transformed Drosophila melanogaster S2 Cells. Biotechnology Letters 21: 729-733, 1999.

    4. Cowger NL, O’Connor KC, Hammond TG, Lacks DJ, Navar GL: Characterization of Bimodal Cell Death of Insect Cells in a Rotating-Wall Vessel and Shaker Flask. Biotechnol Bioeng, 64:14-26, 1999. [ View Abstract ]

    5. Francis KM, O'Connor KC and Spaulding GF: Cultivation of Fall Armyworm Ovary Cells in Simulated Microgravity. In Vitro Cell Dev Bio Anim 33: 332-6, 1997. [ View Abstract ]

    6. Cowger NL, O’Connor KC, Bivins JE: Influence of Simulated Microgravity on the Longevity of Insect-Cell Culture. Enzyme and Microbial Technology 20: 326-332, 1997. [ View Abstract ]

Liver / Pancreas

    118. Murray H.E., Padget, M.B, Downing, R.: Preservation of glucose responsiveness in human islets maintained in a rotational cell culture system. Molecular and Cellular Endocrinology 238: 39-49, 2005 [ View Abstract ]

    119. Coward SM, Selden C, Mantalaris A, Hodgson HJ: Proliferation Rates of HepG2 Cells Encapsulated in Alginate Are Increased in a Microgravity Environment Compared With Static Cultures. Artif Organs 29(2): 152-8, Feb 2005. [ View Abstract ]

    120. Song C, Duan XQ, Li X, Han LO, Xu P, Song CF, Jin LH: Experimental Study on Islet Cells in Rats Under Condition of Three-dimensional Microgravity. Zhonghua Wai Ke Za Zhi Sept; 42(9): 559-61, 2004. [ View Abstract ]

    121. [Abstract in English, Article in Chinese]
    Zhang SQ, Gao SJ, Jiang QY, Lao QL, Feng DY: [Selection of Scaffolds of Rat Hepatocytes in Three-dimensional Culture Under Simulated Microgravity]. Shi Yan Sheng Wu Xue Bao Feb; 37(1):67-71, 2004.

    Song C, Duan XQ, Li X, Han LO, Xu P, Song CF, Jin LH: Experimental Study of Rat Beta Islet Cells Cultured under Simulated Microgravity Conditions. Acta Biochim Biophys (Shanghai) 36: 47-50, 2004. [ View Abstract ]

    122. Rutzky L, Bilinzki Z, Kloc M, Phan T, Zhang H, Katz S, Stepkowski S: Microgravity Culture Conditions Reduces Immunogenicity And Improves Function Of Pancreatic Islets. Transplantation 74: 13-21 July 2002 [ View Abstract ]

    123. Brown LA, Arterburn LM, Miller AP, Cowger NL, Hartley SM, Andrews A, Silber PM, Li AP: Maintenance of Liver Functions in Rat Hepatocytes Cultured as Spheroids in a Rotating Wall Vessel. In Vitro Cell Dev Biol Anim Jan; 39: 13-20,2003. [ View Abstract ]

    126. Cameron DF, Hushen JJ, Dejarlais T, Colado L, Wolski KM, Sanberg PR, Saporta S: A Unique Cytoplasmic Marker for Extratesticular Sertoli Cells, Cell Transplant 11:507-12, 2002. [ View Abstract ]

    127. Cameron DF, Hushen JJ, and Nazian SJ, Formation of Insulin-Secreting, Sertoli-Enriched Tissue Constructs by Microgravity Cocultures of Isolated Pig Islets and Rat Sertoli cells, In Vitro Cell Dev Biol Anim 37:490-8, 2001. [ View Abstract ]

    128. Tobin BW, Leeper-Woodfored SK, Hashemi BB, Smith SM, and Sams CF, Altered TNF-Alpha, Glucose, Insulin, and Amino Acids in Islets of Langerhans Cultured in a Microgravity Model System, Am J Physiol Endocrinol Metab 280:E92-102, 2001 [ View Abstract ]

    129. Khaoustov VI, Risin D, Pellis NR, Yoffe B.: Microarray Analysis of Genes Differentially Expressed in HEPG2 Cells Cultured in Simulated Microgravity: Preliminary Report. In Vitro Cell Dev Biol Anim 37:84-8, 2001. [ View Abstract ]

    130. Rutzky L, Kloc M, Bilinski S, Phan T, Zhang H, Stepkowski SM, Katz S.: Microgravity Culture Conditions Decrease Immunogenicity but Maintain Excellent Morphology of Pancreatic Islets. Transplant Proc 33:388, 2001.

    131. Dabos KJ, Nelson LJ, Bradnock TJ, Parkinson JA, Sadler IH, Hayes PC, Plevris JN: The Simulated Microgravity Environment Maintains Key Metabolic Functions and Promotes Aggregation of Primary Porcine Hepatocytes. Biochem Biophys Acta 1526:119-30, 2001. [ View Abstract ]

    132. Yoffe B, Darlington GJ, Soriano HE, Krishman B, Risin D, Pellis NR, Khaustov VI: Cultures of Human Liver Cells in Simulated Microgravity Environment. Adv Space Res 24: 829-36, 1999. [ View Abstract ]

    133. Mitteregger R, Vogt G, Rossmanith E, Falkenhagen D., Rotary Cell Culture System (RCCS): A New Method for Cultivation Hepatocytes on Microcarriers. Int J Artif Organs 22:12 816-22, 1999. [ View Abstract ]

    134. Rose MI, Brown DC, Pellis NR, Crisera CA, Colen KL, Longaker MT, Gottes GK: Effects of Microgravity on the Embryonic Pancreas. In Vitro Cell Dev Biol Anim 35:560-3, 1999

    135. Battle T, Maguire T, Moulsdale H, Doyle A., Progressive Maturation Resistance to Microcystin-LR Cytotoxicity in Two Different Hepatospheroidal Models. Cell Biol Toxicol 15:1 3-12, 1999. [ View Abstract ]

    136. Khaoustov VI, Darlington GJ, Soriano HE, Krishnan B, Risen D, Pellis NR, Yoffe B: Induction of Three-Dimensional Assembly of Human Liver Cells by Simulated Microgravity. In Vitro Cell Dev Biol Animal, 35: 501-9. 1999. [ View Abstract ]

    137. Khaoustov V, Darlington G, Soriano H, et al.: Establishment of Three Dimensional Primary Hepatocyte Cultures in Microgravity Environment. Hepatology 22: 231A, 1995.

    138. Meacham CA, Lewis ML: Effect of a Low Shear, Horizontally Rotating Culture System on Embryonic Chick Pancreatic Tissue Function. (Abstract #76) American Society for Gravitational & Space Biology (ASGSB), Poster No. A-8, Oct 23, 1992.

    138b. Luca G ,Calvitti M ,Nastruzzi C ,Macchiarulo G ,Becchetti E , Neri LM ,Capitani S ,Basta G ,Brunetti P ,Calafiore R ,Cameron DF Effects of simulated microgravity on the morphology and function of neonatal porcine cell clusters cultured with and without Sertoli cells. Cell Transplant 15: 55-65, 2006 [ View Abstract ]

Microbiology

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    139. Carterson AJ, Honer zu Bentrup K, Ott CM, Clarke MS, Pierson DL, Vanderburg CR, Buchanan KL, Nickerson CA, Schurr MJ: A549 Lung Epithelial Cells Grown as Three-Dimensional Aggregates: Alternative Tissue Culture Model for Pseudomonas Aeruginosa Pathogenesis. Infect Immun Feb;73(2):1129-40, 2005. [ View Abstract ]

    140. Duray P, Yin S, Ito Y, Bezrukov L, Cox C, Cho M, Fitzgerald W: Invasion of Human Tissue Ex Vivo by Borrelia: Journal of infectious Diseases 191:1747-54 2005. [ View Abstract ]

    141. Ciftcioglu N, Haddad RS, Golden DC, Morrison DR, McKay DS: A Potential Cause for Kidney Stone Formation During Space Flights: Enhanced Growth of Nanobacteria in Microgravity. Kidney Int. 67(2):483-91, Feb 2005. [ View Abstract ]

    142. LaMarca H.L, Ott C.M, Höner zu Bentrup K, LeBlanc C.L, Pierson D.L, Nelson A.B, Scandurro A.B, Whitley G.St.J, Nickerson C.A, and C.A.Morris: Three-Dimensional Growth of Extravillous Cytotrophoblasts Promotes Differentiation and Invasion. Placenta (2005) (in press) [ View Abstract ]

    143. Lynch SV, Brodie EL, Matin A: Role and Regulation of Sigma S in General Resistance Conferred by Low-shear Simulated Microgravity in Escherichia Coli. J Bacteriol Dec; 186(24): 8207-12, 2004. [ View Abstract ]

    144. Nickerson CA, Ott CM, Wilson JW, Ramamurthy R, Pierson DL: Microbial Responses to Microgravity and Other Low-Shear Environments. Microbiol Mol Biol Rev Jun; 68(2): 345-61, 2004.

    145. Nickerson CA, Ott CM: A New Dimension in Modeling Infectious Disease. ASM News 70 (4): 169-175, 2004.

    146. England LS, Gorzelak M, Trevors JT: Growth and Membrane Polarization in Pseudomonas aeruginosa UG2 Grown in Randomized Microgravity in a High Aspect Ratio Vessel. Biochimica et Biophysica Acta 1624: 76-81, 2003. [ View Abstract ]

    147. Nickerson CA, Ott CM, Wilson JW, Ramamurthy R, LeBlanc CL,et al.: Low-Shear Modeled Microgravity: A Global Environmental Regulatory Signal Affecting Bacterial Gene Expression, Physiology, and Pathogenesis. Journal of Microbiological Methods 54:1-11, 2003. [ View Abstract ]

    148. Johanson K, Allen PL, Lewis F, Cubano LA, Hyman LE, Hammond TG: Saccharomyces cerevisiae Gene Expression Changes During Rotating Wall Vessel Suspension Culture, J Appl Physiol. Dec. 2171-80, 2002. [ View Abstract ]

    149. Wilson JW, Ott CM, Ramamurthy R, Porwollik S, McClelland M, Pierson DL, Nickerson CA: Low-Shear Modeled Microgravity Alters the Salmonella Enterica Serovar Typhimurium Stress Response in an RpoS-independent Manner. Applied and Environmental Microbiology 68:5408-5416, 2002. [ View Abstract ]

    150. Wilson JW, Ramamurthy R, Porwollik S, McClelland M, Hammond T, Allen P, Ott CM, Pierson DL, Nickerson CA: Microarray Analysis Identifies Salmonella Genes Belonging to the Low-Shear Modeled Microgravity Regulon, Proc. Natl. Acad. Sci. USA 99: 13807-13812, 2002, 10.1073/pnas.212387899 http://www.pnas.org/cgi/content/abstract/212387899v1 [ View Abstract ]

    151. Demain AL and Fang A: Secondary Metabolism in Simulated Microgravity, Chem Rec 1:333-46, 2001. [ View Abstract ]

    152. Gao Q, Fang A, Pierson DL, Mishra SK, Demain AL: Shear Stress Enhances Microcin B17 Production in a Rotating Wall Bioreactor, But Ethanol Does Not. Appl Microbiol Biotechnol 56:384-7, 2001. [ View Abstract ]

    153. Nickerson CA, Goodwin TJ, Terlonge J, Ott CM, Buchanan KL, Uicker WC, Emami K, LeBlanc C, Ramamurthy R, Clarke MS, Vanderburg CR, Hammond T, Pierson DL: Three-Dimensional Tissue Assemblies: Novel Models for the Study of Salmonella Enterica Serovar Typhimurium Pathogenesis. Infect Immun 69:7106-7120, 2001. [ View Abstract ]

    154. Nickerson CA, Ott M, Mister SJ, Morrow BJ, Burns-Keliher L, Pierson DL: Microgravity as a Novel Environmental Signal Affecting Microbial Virulence. Infect. Immun. 68:3147-3150, 2000. [ View Abstract ]

    155. Meijer A, Siekman JH, Roholl PJM, Ossewararde: Culture of Chlamydia Pneumoniae Under Microgravity Conditions: Effects on Developmental Cycle and Establishment of Chronic Infection (Abstract) IV. European Chlamydia Congress, August 20-23, 2000, Helsinki Finland

    156. Fang A, Pierson DL, Mishra SK, Demain AL: Relief from Glucose Interference in Microcin B17 Biosynthesis by Growth in a Rotating-Wall Bioreactor. Lett Appl Microbiol 31:1 39-41, 2000. [ View Abstract ]

    157. Fang A, Pierson DL, Koenig DW, Mishra SK, and Demain AL: Effect of Simulated Microgravity and Shear Stress on Microcin B17 Production by Escherichia Coli and on its Excretion into the Medium. Appl Environ Microbiol 63: 4090-2, 1997. [ View Abstract ]

    158. Fang A., Pierson DL, Mishra SK, Koenig DW and Demain AL: Gramicidin S Production by Bacillus Brevis in Simulated Microgravity. Curr Microbiol 34: 199-204, 1997. [ View Abstract ]

    159. Fang A, Pierson DL, Mishra SK, Koenig DW and Demain AL: Secondary Metabolism in Simulated Microgravity: B-Lactam Production by Streptomyces Clavuligerus. J Ind Microbiol Biotechnol 18: 22-5, 1997. [ View Abstract ]

    159a. Carvalho HM, Teel LD, Goping G, O’Brien AD. A three-dimensional tissue culture model for the study of attach and efface lesion formation by enteropathic and enterohaemorrhagic Escherichia coli Cell Microbiol 7: 1771-1781, 2005 [ View Abstract ]

    159b. Shimada N, Sokunbi G, Moorman SJ. Changes in gravitational force affect gene expression in developing organ systems at different developmental times. BMC Dev Biol 5: 10 , 2005 [ View Abstract ]

    159c. zu Bentrup KH, Ramamurthy R, Ott CM, Emami K, Nelman-Gonzalez M, Wilson JW, Richter EG, Goodwin TJ, Alexander JS, Pierson DL, Pellis N, Buchanan KL, Nickerson CA. Three-dimensional organotypic models of human colonic epithelium to study the early stages of enteric salmonellosis. Microbes Infect 8: 1813-1825, 2006 [ View Abstract ]

    159d. Smith YC, Grande KK, Rasmussen SB, O’Brien AD. Novel three-dimensional organoid model for evaluation of the interaction of uropathologenic Escherichia coli with terminally differentiated human urothelial cells. Infect. Immun. 74: 750-757, 2006 [ View Adbstract ]

    159e. Lynch SV, Mukundakrishnan K, Benoit MR, Ayyaswamy PS, Matin A. Escherichia coli biofilms formed under low-shear modeled microgravity in a ground-based system. Appl. Environ. Microbiol. 72: 7701-7710, 2006 [ View Abstract ]

Neural/Neuroendocrine

    1. Saporta S, Willing AE, Shamekh R, Bickford P, Paredes D, Cameron DF: Rapid Differentiation of NT2 Cells in a Sertoli-NT2 Cell Tissue Constructs Grown in the Rotating Wall Bioreactor. Brain Res Bull 64(4): 347-56, Dec 2004. [ View Abstract ]

    2. Cameron DF, Hushen JJ, Colina L, Mallery J, Willing A, Sanberg PR, Saporta S: Formation and Structure of Transplantable Tissue Constructs Generated in Simulated Microgravity From Sertoli Cells and Neuron Precursors. Cell Transplant 13(7-8):755-63, 2004. [ View Abstract ]

    3. Lin HJ, O’Shaughnessy TJ, Kelly J, Ma W: Neural Stem Cell Differentiation in a Cell-collagen-bioreactor Culture System. Develop. Brain Res 153 (2):163-73, Nov 2004. [ View Abstract ]

    4. Wang SS and Good TA: Effect of Culture in a Rotating Wall Bioreactor on the Physiology of Differentiated Neuron-Like PC12 and SH-SY5Y Cells, J Cell Biochem 83:574-84, 2001. [ View Abstract ]

    5. Low, H.P., Savarese, T.M., and Schwartz, W.J.: Neural Precursor Cells Form Rudimentary Tissue-Like Structures in a Rotating-Wall Vessel Bioreactor. In Vitro Cell Dev Biol Anim 37: 141-147, 2001. [ View Abstract ]

    6. Lelkes P. et al.: Simulated Microgravity Conditions Enhance Differentiation of Cultured PC12 Cells Towards the Neuroendocrine Phenotype. InVitro Cell Dev Biol Anim 34: 316-25, 1998. [ View Abstract ]

    7. Shamekh R, Cameron DF, Willing AE, Saporta S.
    The role of connexins in the differentiation of NT2 cells in Sertoli-NT2 cell tissue constructs grown in the rotating wall bioreactor. Exp Brain Res 170: 277-284, 2006
    [ View Abstract ]

    8. Di Loreto S ,Sebastiani P ,Benedetti E ,Zimmitti V ,Caracciolo V , Amicarelli F ,Cimini A ,Adorno D . Transient maintenance in bioreactor improves health of neuronal cells. In Vitro Cell Dev Biol Anim 42: 134-142, 2006 [ View Abstract ]

     

Prostate

    1. Clejan S, O’Connor K and Rosenweig N: Tri-dimensional Prostate Cell Cultures in Simulated Microgravity and Induced Changes in Lipid Second Messengers and Signal Transduction. J Cell Mol Med 5:60-73, 2001. [ View Abstract ]

    2. Margolis L, Hatfill S, Chuaqui R, Vocke C, Emmert-Buck M, Linehan WM and Duray PH: Long Term Organ Culture of Human Prostate Tissue in a NASA-Designed Rotating Wall Bioreactor. J Urol 161: 290-7, 1999. [ View Abstract ]

     

Renal

    1. Cowger NL, Benes E, Allen PL, and Hammond TG: Expression of Renal Cell Protein Markers is Dependent on Initial Mechanical Culture Conditions, J Appl Physiol 92:691-700, 2002. [ View Abstract ]

    2. Kaysen JH, Campbell WC, Majewski RR, Goda FO, Navar GL, Lewis FC, Goodwin TJ, Hammond TG: Select De Novo Gene and Protein Expression During Renal Epithelial Cell Culture in Rotating Wall Vessels is Shear Stress Dependent. J Memb Biol 168: 77-89, 1999. [ View Abstract ]

Salivary Gland

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    1. Hatfill SJ, Margolis LB and Duray P: In Vitro Maintenance of Normal and Pathological Human Salivary Gland Tissue in a NASA-Designed Rotating Wall Vessel Bioreactor. Cell Vision 3: 397-401, 1996.

    2. Lewis ML, Moriarity DM and Campbell PS: Use of Microgravity Bioreactors for Development of an In Vitro Rat Salivary Gland Cell Culture Model. J Cell Biochem 51: 265-73, 1993. [ View Abstract ]

Signaling