Providing Quality 3D Cell Culture Systems for
Tissue Engineering and Stem Cell Culture Applications

Miscellaneaous


 Rotary culture promotes the proliferation of MCF-7 cells encapsulated in three-dimensional collagen-alginate hydrogels via activation of the ERK1/2-MAPK pathway.

Zheng H, Tian W, Yan H, Yue L, Zhang Y, Han F, Chen X, Li Y. Biomed Mater. 2012 Feb;7(1):015003. doi: 10.1088/1748-6041/7/1/015003. [Abstract]

Rotating cell culture systems for human cell culture: human trophoblast cells as a model.

Zwezdaryk KJ, Warner JA, Machado HL, Morris CA, Höner zu Bentrup K. J Vis Exp. 2012 Jan 18;(59). pii: 3367. doi: 10.3791/3367[Abstract]

Effects of Simulated Microgravity on Expression Profile of MicroRNA in Human Lymphoblastoid Cells.

Mangala LS, Zhang Y, He Z, Emami K, Ramesh GT, Story M, Rohde LH, Wu H. J Biol Chem. 286(37):32483-90, 2011 [Abstract]

Simulated microgravity, erythroid differentiation, and the expression of transcription factor GATA-1 in CD34+ cells.
Zheng L, Liu JZ, Hu YW, Zhong TY, Xiong SL, Wang W, Wang Q. Aviat Space Environ Med. 82(5):513-7, 2011

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Simulated microgravity-induced epigenetic changes in human lymphocytes.
Singh KP, Kumari R, Dumond JW. J Cell Biochem. 111(1):123-9, 2010

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Xenopus development from late gastrulation to feeding tadpole in simulated microgravity.
Olson WM, Wiens DJ, Gaaul TL, Rodriguez M, Hauptmeier CL.  Intl J Dvl Biol. ;54:167-74.

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Cultivation of Lacrimal gland acinar cells in a microgravity environment.
Schrader S, Kremling C, Clinger M, Lagua H, Geerling G.  Br J Ophthalmol. 93: 1121-1125, 2009

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Oxygen transport and consumption by suspended cells in microgravity: A multiphase analysis.
Kwon O, Devarakonda SB, Sankovic JM, Banerjee RK.  Biotechnol Bioeng 99:99-107, 2008

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In situ monitoring of 3D in vitro cell aggregation using an optical imaging system.
Sawyer N, Worrall L, Crowe J, Waters, S, Shakesheff K, Rose F, Morgan S.  Biotechnol Bioeng 100:159-167, 2007

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Morphological characteristics and proliferation of keratocytes cultured under simulated microgravity.
Chen J, Chen R, Gao S.  Artif Organs 31: 722-731, 2007

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Does reduced gravity alter cellular responses to ionizing radiation?
Manti L. Radiat Environ Biophys 45: 1-8, 2006

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Nitric oxide affects preimplantation embryonic development in a rotating wall vessel bioreactor simulating microgravity.
Cao YJ, Fan XJ, Shen Z, Ma BH, Duan EK.  Cell Biol. Int. 31: 24-29, 2007

[Abstract]

Gene expression and survival changes in Saccharomyces cerevisiae during suspension culture.
Johanson K, Allen PL, Gonzalez-Villalobos RA, Baker CB, D'Elia R, Hammond TG.: Biotechnol Bioeng 93: 1050-1059, 2006

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Changes in gravitational force affect gene expression in developing organ systems at different developmental times.
Shimada N, Sokunbi G, Moorman SJ:  BMC Dev Biol 5: 10 , 2005.

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Morin Sulphates/Glucuronides Enhance Macrophage Function in Microgravity Culture System.
Hsieh C, Chao P, Fang S,:  European Journal of Clinical Investigation 35, 591-596, 2005

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“Modeled Microgravity” Affects Cell Response to Ionizong Radiation and Increase Genomic Damage.
Canova S, Fiorasi F, Mognato M, Grifalconi M, Reddi E, Russo A, Celotti L: Radiat Res 163: 191-199, 2005.

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Continuous Glucose Monitoring and Control in a Rotating Wall Perfused Bioreactor.
Xu Y, Sun J, Mathew G, Jeevarajan AS, Anderson MM: Biotechnol Bioeng. 86: 473-477, 2004.

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Long-Term Continuous Monitoring of Dissolved Oxygen in Cell Culture Medium for Perfused Bioreactors Using Optical Oxygen Sensors.
Gao FG, Jeevarajan AS, Anderson MM: Biotechnol Bioeng. 86: 425-433, 2004.

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Increase in Synthesis of Human Monoclonal Antibodies by Transfected Sp2/0 Myeloma Mouse Cell Line Under Conditions of Microgravity.
Foster LJ, Catzel D, Atwa S, Zarka M, Mahler SM:  Biotechnol Lett. Aug. 25: 1271-1274, 2003.

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Simulated Conditions Of Microgravity Suppress Progesterone Production by Luteal Cells of the Pregnant Rat.
Bhat GK, Yang H, Sridaran R:  J Gravit Physiol Dec; 8: 57-66, 2001.

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Monitoring and Controlling the Dissolved Oxygen (DO) Concentration Within the High Aspect Ration Vessel (HARV).
Saarinen MA, Reece JS, Arnold MA, Murhammer DW:  Biotechnol. Prog. 19; 1335-1341, 2003.

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RWPV Bioreactor Mass Transport: Earth-Based and in Microgravity.
Begley CM, Kleis SJ:  Biotechnol Bioeng, 80: 465-76, 2002.

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A Countermeasure to Ameliorate Immune Dysfunction in In Vitro Simulated Microgravity Environment: Role of Cellular Nucleotide Nutrition.
Hales NW, Yamauchi K, Martinez AA, Sundaresan A, Pellis NR and Kulkarni AD: In Vitro Cell Dev Biol (Animal) 38(4):213-217, 2002.

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Space Immunology and Countermeasure Research in Modeled Microgravity.

Kulkarni AD, Yamauchi K. Taga M, Savary CA, Sundaresan A and Pellis NR:  Proceedings of the Aerospace Sciences and Conference, AIAA-2002-0325:1-6, 2002. 

On-Line Measurement of Glucose in a Rotating Wall Perfused Vessel Using an Amperometric Glucose Sensor.
Yuanhang Xu, Antony S. Jeevarajan, James M. Gay, Thomas D Taylor, Melody M. Anderson:  J The Electrochemical Society, 149: H103- H106, 2002

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Continuous pH Monitoring in a Perfused Bioreactor System Using an Optical pH Sensor.
Jeevarajan AS, Vani S, Taylor TD, Anderson MM:  Biotechnol Bioeng 78: 467-472, 2002.

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A Critical Period for Functional Vestibular Development in Zebrafish.
Moorman SJ, Cordova R, Davies SA:  Dev Dyn 223: 285-291, 2002.

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Nutrition Countermeasure and Immune Function in Microgravity.

Kulkarni AD, Yamauchi K. and Pellis NR.  Proceedings of the 2nd Pan Pacific Basin Workshop on Microgravity Sciences, Pasadena, CA. April 2001BT1099:1-10, 2001.[Abstract]

NASA Biotechnology: Cell Science in Microgravity.

Jessup JM, and Pellis NR:  In Vitro Cell Dev Biol Anim 37: 2 p preceding 63, 2001.[PubMed ID:11332737]

The Fluid Dynamic and Shear Environment in The NASA/JSC Rotating-Wall Perfused Vessel Bioreactor.
Begley CM and Kleis SJ:  Biotechnol Bioeng 70: 32-40, 2000.

[Abstract]

Numerical Model and Experimental Validation of Microcarrier Motion in a Rotating Bioreactor.
Pollack SR, Meaney DF, Levine EM, Litt M, Johnston ED:  Tiss Engin 6: 519-530, 2000.

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Membrane Potential Mediates H+-ATPase Dependence of “Degradative Pathway” Endosomal Fusion.
Hammond T, Gonda F, Navar G, Campbell W, Majewski R, Galvan D, Pontillion F, Kaysen J, Goodwin T, Paddock S and Verroust P:  J Memb Biol 162: 157-167, 1998.

[Abstract]

Advances in Cellular Construction.

Spaulding GF, Jessup JM and Goodwin TJ:  J Cell Biochem 51: 249-251, 1993 [PubMed ID: 8501125]

Responses Of Gravity Level Variations On The NASA JSC Bioreactor System.

Tsao YD, Goodwin TJ, Wolf DA, Spaulding GF:  Physiologist 35: Suppl S49-50, 1992.[PubMed ID: 1589533]

Cell Culture for Three-Dimensional Modeling in Rotating Wall Vessels: An Application of Simulated Microgravity
Schwarz RP, Goodwin TJ, Wolf DA: . J Tissue Culture Methods 14: 51-58, 1992.

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Analysis of Gravity-Induced Particle Motion and Fluid Perfusion Flow in the NASADesigned Rotating Zero-Head-Space Tissue Culture Vessel.
Wolf DA, Schwarz RP:  NASA Technical Paper 3143, October, 1991.

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The Physical Basis of Gravity Stimulus Nullification by Clinostat Rotation.
Dedolph RR and Dipert MH:  Plant Physiol 47: 756-764, 1971.

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Modulation of Human Endothelial Cell Behavior in Simulated Microgravity.
Carrlsson SI, Bertilaccio MT, Ascari I, Bradamante S, Maier JA. J Gravit Physiol 9: P273-274, 2002.

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Comparative Effectiveness of a Clinostat and a Slow-Turning Lateral Vessel at Mimicking the Ultrastructural Effects of Microgravity in Plant Cells.
Moore R. Ann Bot (Lond). 66: 541-549, 1990.

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Simulated Weightlessness in the Design and Exploitation of a NMR-Compatible Bioreactor.
Bradamante S, Barenghi L, Villa A. Biotechnol Prog. 20: 1454-1459, 2004.