Providing Quality 3D Cell Culture Systems for
Tissue Engineering and Stem Cell Culture Applications

Hematopoietic System

Chondrocytes and bone marrow-derived mesenchymal stem cells undergoing chondrogenesis in agarose hydrogels of solid and channelled architectures respond differentially to dynamic culture conditions.

Sheehy EJ, Buckley CT, Kelly DJ., J Tissue Eng Regen Med. Epub Jan 2011 [Abstract]

Simultaneous expansion and harvest of hematopoietic stem cells and mesenchymal stem cells derived from umbilical cord blood.

Kedong S, Xiubo F, Tianqing L, Macedo HM, LiLi J, Meiyun F, Fangxin S, Xuehu M, Zhanfeng C 21(12):3183-93, 2010 [Abstract]

The effect of simulated microgravity on human mesenchymal stem cells cultured in an osteogenic differentiation system: a bioinformatics study.

Sheyn D, Pelled G, Netanely D, Domany E, Gazit D. Tissue Eng Part A. 16(11):3403-12, 2010 [Abstract]

Simulated microgravity-induced epigenetic changes in human lymphocytes.

J Cell Biochem 111:123-129, 2010 [Abstract]

Cellular and genetic adaptation in low-gravity environments.

Sundaresan A, Pellis NR. Ann N Y Acad Sci. 1161:135-46, 2009 [Abstract]

The influence of leptin on the activity of lung lymphocytes under simulated microgravity.

Li X, Liu CT, Zhou H. Eur J App Physiol. 107: 335-44, 2009 [Abstract]

Sub-mitogenic phorbol myristate acetate co-stimulation rescues the PHA-induced activation of both naïve and memory T cells cultured in the rotating-wall vessel bioreactor.

Simmons DM, Gardner EM, Lelkes PI. Cell Biol Intl. 33:882-6, 2009 [Abstract]

Simulated microgravity decreases DNA repair capacity and induces DNA damage in human lymphocytes.

Kumari R, Singh KP, Dumond JW Jr. J. Cell Biochem.107:723-31, 2009 [Abstract]

Gene expression alterations in activated human T-cells induced by modeled microgravity.

Ward NE, Pellis NR, Risin SA, Risin D.; J. Cell. Biochem. 99: 1187-1202, 2006 [Abstract]

Dynamic culture in a rotating-wall vessel bioreactor differentially inhibits murine T-lymphocyte activation by mitogenic stimuli upon return to static conditions in a time- dependent manner.

Simons DM, Gardner EM, Lelkes PI:  J Appl Physiol 100: 1287-1292, 2006. [Abstract] [Full Text] [Full Text pdf]

Functional recovery of peripheral blood mononuclear cells in modeled microgravity.

Ritz BW, Lelkes PI, Gardner EM; FASEB J. 20: 305-307, 2006. [Abstract] [Full Text pdf]

Impact of Modeled Microgravity on Migration, Differentiation, and Cell Cycle Control of Primitive Human Hematopoietic Progenitor Cells.

Plett PA, Abonour R, Frankovitz SM, Orschell CM; Experimental Hematology 32: 773-781, 2004. [Abstract]

Effect of Simulated Microgravity on the Production of IL-12 by PBMC’s.

Bakos A, Varkonyi A, Minarovits J, Batkai L:  J Gravit Physiol. 9: 293-294, 2002. [Abstract]

Three-Dimensional Binding of Epidermal Growth Factor Peptides in Colonic Tissues Produced From Rotating Bioreactor.

Kaeffer B, Trubuil A, Kervrann C, Pardini L, Cherbut C:  In Vitro Cell Dev Biol Anim 38: 436- 439, 2002. [Abstract]

Proliferation of Human Hematopoietic Bone Marrow Cells in Simulated Microgravity.

Plett PA, Frankovitz SM, Abonour R, Orschell-Traycoff CM; In Vitro Cell Dev Biol Anim 37: 73-78, 2001. [Abstract]

Erythroid Cell Growth and Differentiation In Vitro in the Simulated Microgravity Environment of the NASA Rotating Wall Vessel Bioreactor.

Sytkowski AJ and Davis KL; In Vitro Cell Dev Biol Anim 37: 79- 83, 2001. [Abstract]

Simulated Microgravity Impairs Respiratory Burst Activity in Human Promyelocytic Cells.

Hughes JH and Long JP; In Vitro Cell Dev Biol Anim 37: 209-215, 2001. [Abstract]

Multiple Interleukin-2 Signaling Pathways Differentially Regulated by Microgravity.
Licato LL, Grimm EA; Immunopharmacology 44: 273-9, 1999. [Abstract]
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