Providing Quality 3D Cell Culture Systems for
Tissue Engineering and Stem Cell Culture Applications

Cartilage/Chondrocytes

Simulated microgravity using a rotary cell culture system promotes chondrogenesis of human adipose-derived mesenchymal stem cells via the p38 MAPK pathway. 

Yu B, Yu D, Cao L, Zhao X, Long T, Liu G, Tang T, Zhu Z. Biochem Biophys Res Commun.;414(2):412-8 Oct 2011 [Abstract]

Chondrocytes and bone marrow-derived mesenchymal stem cells undergoing chondrogenesis in agarose hydrogels of solid and channelled architectures respond differentially to dynamic culture conditions.

Sheehy EJ, Buckley CT, Kelly DJ., J Tissue Eng Regen Med. Epub Jan 2011 [Abstract]

A validated model of GAG deposition, cell distribution and growth of tissue engineered cartilage cultured in a rotating bioreactor.

Nikolaev NI, Obradovic B, Versteeg HK, Lemon G, Williams DJ. Biotechnol Bioeng 105:842-853, 2010 [abstract]

Computational fluid dynamics modeling of momentum transport in rotating wall perfused bioreactor for cartilage tissue engineering.
Cinbiz MN, Tığli RS, Beşkardeş IG, Gümüşderelioğlu M, Colak U. J Biotechnol; 150(3):389-95; 2010 [Abstract]

Cross-linking density alters early metabolic activities in chondrocytes encapsulated in poly(ethylene glycol) hydrogels and cultured in the rotating wall vessel.

Villanueva I, Klement BJ, Von Deutsch D, Bryant SJ. Biotechnol Bioeng. 102:1242-50, 2009. [Abstract]

Rotating three-dimensional dynamic culture of adult human bone marrow-derived cells for tissue engineering of hyaline cartilage.

Sakai S, Mishima H, Ishii T, Akaogi H, Yoshioka T, Ohyabu Y, Chang F, Ochiai N, Uemura T.; Journal Orthop Res.27:517-21, 2009. [Abstract]

Cell-Nanofiber-Based Cartilage Tissue Engineering Using Improved Cell Seeding, Growth Factor, and Bioreactor Technologies.

Li WJ, Jiang YJ, Tuan RS. Tissue Eng Part A 14: 639-648, 2008 [Abstract]

Engineering of Functional Cartilage Tissue Using Stem Cells from Synovial Lining: A Preliminary Study.

Pei M, He F, Kish VL, Vunjak-Novakovic G. Clin Orthop Relat Res 466: 1880-1889, 2008 [Abstract] [Full Text] [Full Text pdf]

Engineering of rat articular cartilage on porous sponges: effects of tgf Beta 1 and microgravity bioreactor culture.

Emin N, Koc A, Durkut S, Elcin AE, Elcin YM. Artif Cells Blood Substit Immobil Biotechnol 36: 123137, 2008 [Abstract]

An ex vivo model for chondrogenesis and osteogenesis.

Pound JC, Green DW, Roach HI, Mann S, Oreffo RO. Biomaterials 28:2839-2849, 2007 [Abstract]

Strategies to Promote Chondrogenesis and Osteogenesis from Human Bone Marrow Cells and Articular Chrondrocytes Encapsulated in Polysaccharide Templates.

Pound JC, Green DW, Chaudhuri JB, Mann S, Roach HI, Oreffo RO. Tissue Eng 12:2789-2799, 2006 [Abstract]

Cartilaginous tissue formation from bone marrow using rotating wall vessel (RWV) bioreactor.

Ohyabu Y, Kida N, Kojima H, Taguchi T, Tanaka J, Uemura T.; Biotechnol. Bioeng. 95: 1003-1008, 2006 [Abstract]

Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds and rotating bioreactors.

Marolt D, Augst A, Freed LE, Vepari C, Fajardo R, Patel N, Gray M, Farley M, Kaplan D, Vunjak-Novakovic G. Biomaterials 27: 6138-6149, 2006 [Abstract]

Development and remodeling of engineered cartilage-explant composites in vitro and in vivo.

Tognana, E., Padera, R.F., Chen, F., Vunjak-Novakovic, G., Freed, L.E.; Osteoarthritis and Cartilage 13: 896-905, 2005 [Abstract]

Adjacent Tissue (Cartilage, Bone) Affect the Functional Integration of Engineered Calf Cartilage in vitro.

Tognana, E., Chen, F., Padera, R.F., Leddy, H.A, Christensen, S.E., Guilak, F., Vunjak-Novakovic, G., Freed, L.E.; Osteoarthritis and Cartilage 13: 129-138, 2005 [Abstract]

Low-density Cultures of Bovine Chondrocytes: Effects of Scaffold Material and Culture System.

Hu JC, Athanasiou KA;  Biomaterials 26:2001-2012, 2005. [Abstract]

Chondrogenesis of Aged Human Articular Cartilage in a Scaffold-Free Bioreactor

Marlovits S, Tichy B, Truppe M, Gruber D, Vecsei V. Tissue Eng. 9: 1215-1226, 2003. [Abstract]

Collagen Expression in Tissue Engineered Cartilage of Aged Human Articular Chondrocytes in a Rotating Bioreactor

Marlovits S, Tichy B, Truppe M, Gruber D, Schlegel W.; Int. Jour. Artificial Organs 26: 319-330, 2003. [Abstract]

Articular Cartilage Bioreactors and Bioprocesses

Darling EM, Athanasiou KA; Tissue Eng. 9: 9-26, 2003. [Abstract]

Bioreactors Mediate the Effectiveness of Tissue Engineering Scaffolds

Pei M, Solchaga LA, Seidel J, Zenf L. Vunjak-Novakovic G, Caplan AI, Freed LE; FASEB J 16:1691-4, 2002. [Abstract] [Full Text pdf]

Growth factors for sequential cellular de-and re-differentiation in tissue engineering

Pei M, .Seidel J, G.Vunjak-Novakovic,and.Freed L.E. Biochem Biophysl Res Commun 294, 149-154, 2002 [Abstract]

Bioreactor Studies of Native and Tissue Engineered Cartilage

Vunjak-Novakovic G, Obradovic B, Martin I, Freed LE: Biorheology 39:259-268, 2002. [Abstract]

Tissue Engineering with Chondrocytes

Koch RJ, Gorti GK: Facial Plast Surg 18:59-68, 2002. [Abstract]

IGF-I and Mechanical Environment Interact to Modulate Engineered Cartilage Development

Gooch KJ, Blunk T, Courter DL, Sieminski AL, Bursac PM, Vunjak-Novakovic G and Freed L.E.; Biochem Biophys Res Commun 286: 909-15, 2001. [Abstract]

Modulation of the Mechanical Properties of Tissue Engineered Cartilage

Martin I, Obradovic B, Treppo S, Grodzinsky AJ, Langer R, Freed LE, and Vunjak-Novakovic G; Biorheology 37:141-7, 2000. [Abstract]

Growth of Tissue-Engineered Human Nasoseptal Cartilage in Simulated Microgravity

Falsafi S and Koch RJ; Arch Otolaryngol Head Neck Surg 126:759-765, 2000. [Abstract][Full Text] [Full Text pdf]

Bioreactor Cultivation Conditions Modulate the Composition and Mechanical Properties of Tissue-Engineered Cartilage

Vunjak-Novakovic G, Martin I, Obradovic B, Treppo S, Grodzinsky AJ, Langer R, and Freed L; J Orthop Res 17: 130-138, 1999. [Abstract]

Gas Exchange is Essential for Bioreactor Cultivation of Tissue Engineered Cartilage

Obradovic B, Carrier R, Vunjak-Novakovic G and Freed LE;  Biotechnol Bioeng 63: 197-205, 1999. [Abstract]

Frontiers in Tissue Engineering –In Vitro Modulation of Chondrogenesis.

Freed L, Martin I and Vunjak-Novakovic G; Clinical Orthopedics and Related Research 367S:S46-S58, 1999. [Abstract]

Chondrogenesis in a Cell-Polymer Bioreactor system

Freed L. et al: Exp Cell Res 240: 58-65, 1998. [Abstract]

Collagen in Tissue-Engineered Cartilage: Types Structure, and Crosslinks

Riesle J, Hollander AP, Langer R, Freed LE, and Vunjak-Novakovic G; J Cell Biochem 71: 313-27, 1998. [Abstract]

Three Dimensional Culture of Bovine Chondrocytes in Rotating-Wall Vessels.

Baker TL and Goodwin TJ; In vitro Cell Dev Biol Anim 33: 358-365, 1997. [Abstract]

Chondrogenesis in Aggregates of Embryonic Limb Cells Grown in a Rotating Wall Vessel

Duke PJ, Daane E, Arizpe J and Montufar-Solis D; Adv. Space Research 17: 289-293, 1996. [Abstract]

Studies of Chondrogenesis in Rotating Systems

Duke PJ, Daane EL, Montufar-Solis D: J Cell Biochem 51: 274282,1993. [Abstract]

Cultivation of Cell-Polymer Cartilage Implants in Bioreactors
Freed LE, Vunjak-Novakovic G and Langer R; J Cell Biochem 51: 257-64, 1993. [Abstract]
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