Providing Quality 3D Cell Culture Systems for
Tissue Engineering and Stem Cell Culture Applications

Bone

Freeze-dried human serum albumin improves the adherence and proliferation of mesenchymal stem cells on mineralized human bone allografts.

Weszl M, Skaliczki G, Cselenyák A, Kiss L, Major T, Schandl K, Bognár E, Stadler G, Peterbauer A, Csönge L. J Orthop Res. 2012 Mar;30(3):489-96. [abstract]

Cementum protein 1 (CEMP1) induces differentiation by human periodontal ligament cells under three-dimensional culture conditions. 

Hoz L, Romo E, Zeichner-David M, Sanz M, Nuñez J, Gaitán L, Mercado G, Arzate H., Cell Biol Int.2012 Feb 1;36(2):129-36. [abstract]

3D sample preparation for orthopaedic tissue engineering bioreactors. 

Cartmell SH, Rathbone S, Jones G, Hidalgo-Bastida LA. (Textbook chapter in 3D Cell Culture: Methods and Protocols, ISBN 978-1-60761-983-3) [abstract] [publisher page for texbook]

Bioreactor systems for bone tissue engineering.

Rauh J, Milan F, Günther KP, Stiehler M. Tissue Eng Part B Rev. 2011 Aug;17(4):263-80. [abstract]

RCCS enhances EOE cell proliferation and their differentiation into ameloblasts.

Li P, Zhang Y, Wang YM, Duan CM, Hao T, Wu BL, Wang CY. . Mol Biol Rep. Epub June 2011 [abstract]

Enhancement of matrix production and cell proliferation in human annulus cells under bioreactor culture.

Yang X, Wang D, Hao J, Gong M, Arlet V, Balian G, Shen FH, Li XJ. Tissue Eng Part A.; 17(11-12):1595-603, June 2011 [abstract]

Bone tissue engineering bioreactors: dynamic culture and the influence of shear stress.

Yeatts AB, Fisher JP. Bone; 48(2):171-81. 2011[abstract]

Microarray profile of gene expression during osteoclast differentiation in modelled microgravity.

Sambandam Y, Blanchard JJ, Daughtridge G, Kolb RJ, Shanmugarajan S, Pandruvada SN, Bateman TA, Redd., J Cell Biochem. 2010 Dec 1;111(5):1179-87. [abstract]

The effect of simulated microgravity on human mesenchymal stem cells cultured in an osteogenic differentiation system: a bioinformatics study.

Sheyn D, Pelled G, Netanely D, Domany E, Gazit D. Tissue Eng Part A. 16(11):3403-12, 2010 [abstract]

Enhanced cell ingrowth and proliferation through three dimensional nano composite scaffolds with controlled pore structures.

Lee KW, Wang S, Dadsetan M, Yaszemski MJ, Lu L.  Biomacromolecules. 11:682-9, 2010. [abstract] [full text] [full text pdf]

Analysis of the attachment and differentiation of three-dimensional rotary wall vessel cultured human preosteoblasts on dental implant surfaces.
Ko YJ, Zaharias RS, Seabold DA, Lafoon JE, Schneider GB.  Int J Oral Maxilofac Implants 25:722-728, 2010 [Abstract]
 
Establishment of three-dimensional tissue- engineered bone constructs under microgravity-simulating conditions.
Jin F, Zhang Y, Xuan K, He D, Deng T, Tang L, Lu W, Duan Y.  Artif Organs 34: 118-125, 2009 [Abstract]

NASA approved rotary bioreactor enhances proliferation and osteogenesis of human periodontal ligament stem cells.
Li S, a Z, Niu Z, Qian H, Xuan D, Hou R, Ni L.  Stem Cells Dev. 18:1273-82, 2009 [Abstract]
 
Global transcriptome analysis in mouse calvarial osteoblasts highlights sets of genes regulated by modeled microgravity and identifies a "mechanoresponsive osteoblast gene signature"
Capulli M, Rufo A, Teti A, Rucci N.  J. Cell Biochem. 107:240-52, 2009 [Abstract]

Fabrication, characterization, and in vitro evaluation of poly(lactic acid glycolic acid)/nano-hydroxyapatite composite microsphere-based scaffolds for bone tissue engineering in rotating bioreactors
Lv Q, Nair L, Laurencin CT. J Biomed Mater Res A 91:679-691, 2009 [Abstract]

Cell-Nanofiber based cartilage tissue engineering using improved cell seeding, growth factor and bioreactor technologies.
Li WJ, Jiang, YJ, Tuan RS.  Tissue Engineering: Part A. 14: 639-48, 2008 [Abstract]

Osteoblast and Osteoclast Differentiation in Modeled Microgravity.
Saxena R, McDonald J. Ann NY Acad Sci. 1116: 494-498, 2007 [Abstract]

Three-dimensional expansion: in suspension culture of SD rat’s osteoblasts in a rotating wall vessel bioreactor.
Song KD, Liu TQ, Li XQ, Cui ZF, Sun XY, Ma XH.  Biomed Environ Sci 20: 91-98, 2007 [Abstract]

Repair of large osteochondral defects with allogenic cartilaginous aggregates formed from bone marrow-derived cells using RWV bioreactor.

Yoshioka T, Mishima H, Ohyabu Y, Sakai S, Akaogi H, Ishii T, Kojima H, Tanaka J, Ochiai N, Uemura T.  J Orthop Res 25:1291-1298, 2007 [Abstract]

The effect of simulated microgravity on osteoblasts is independent of the induction of apoptosis.
Bucaro MA, Zahm AM, Risbud MV, Avyaswamy PS, Mukundakrishnan K, Steinbeck MJ, Shapiro IM, Adams CS. J Cell Biochem 102: 483-495, 2007 [Abstract]

Encapsulation and osteoinduction of human periodontal ligament fibroblasts in chitosan-hydroxyapatite microspheres
Inac B, Eser Elcin A, Koc A, Balos K, Parlar A, Murat Elcin Y.  Biomed Mater Res A 82: 917-926, 2007 [Abstract]

Could the effect of modeled microgravity on osteogenic differentiation of human mesenchymal stem cells be reversed by regulation of signaling pathways?
Zheng Q, Huang G, Xu Y, Guo C, Xi Y, Pan Z, Wang J. Biol Chem 388: 755-763, 2007 [Abstract]

An ex vivo model for chondrogenesis and osteogenesis.
Pound JC, Green DW, Roach HI, Mann S, Oreffo RO.  Biomaterials 28:2839-2849, 2007 [Abstract]

Strategies to Promote Chondrogenesis and Osteogenesis from Human Bone Marrow Cells and Articular Chrondrocytes Encapsulated in Polysaccharide Templates.
Pound JC, Green DW, Chaudhuri JB, Mann S, Roach HI, Oreffo RO. Tissue Eng 12:2789-2799, 2006 [Abstract]

Modeled microgravity stimulates osteoclastogenesis and bone resorption by increasing osteoblast RANK/OPG ratio.
Rucci N, Rufo A, Alamanou M, Teti A. J. Cell. Biochem. 100: 464-473, 2007 [Abstract]

Fabrication and detection of tissue-engineered bones with bio-derived scaffolds in a rotating bioreactor.
Song K, Yang Z, Liu T, Zhi W, Li X, Deng L, Cui Z, Ma X.  Biotechnol. Appl. Biochem. 45(pt 2): 65-74, 2006 [Abstract]

Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds and rotating bioreactors.
Marolt D, Augst A, Freed LE, Vepari C, Fajardo R, Patel N, Gray M, Farley M, Kaplan D, Vunjak-Novakovic G.  Biomaterials 27: 6138-6149, 2006 [Abstract]
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